Interleukin-4 increases cortisol release and decreases adrenal androgen release from bovine adrenal cells

• Published in: Domestic animal endocrinology Vol. 34; no. 4; pp. 372 - 382
• Main Authors: Woods, Alison M., Judd, Allan M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2008; [Amsterdam; New York]: Elsevier Science Pub. Co
• Subjects: Adrenal; adrenal cortex; Adrenal Glands - drug effects; Adrenal Glands - metabolism; Androgen; androgens; Androgens - secretion; Animals; cattle; Cattle - metabolism; Cells, Cultured; corticotropin; Cortisol; cultured cells; Cytokine; Dose-Response Relationship, Drug; hormonal regulation; hormone secretion; Hydrocortisone - secretion; Interleukin-4; Interleukin-4 - metabolism; Interleukin-4 - pharmacology; interleukin-4 receptors; physiological regulation; receptors; Receptors, Interleukin-4 - metabolism; Stress, Physiological - metabolism; Time Factors; tissue distribution; Zona Fasciculata - metabolism; Zona Reticularis - metabolism; Interleukin-4; Cortisol; Androgen; Adrenal; Cytokine

ACTH is the primary regulator of adrenal function during acute stress. However, during chronic inflammatory stress additional factors play a major role in the regulation of adrenal secretion. Many cytokines circulate in the blood and are synthesized and released from adrenal tissue. Furthermore, the...