MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport - George, Richard T.; Abuhatzira, Liron; Stoughton, Susan M.; Karathanasis, Sotirios K.; She, Dewei; Jin, ChaoYu; Buss, Nicholas A. P. S.; Bakker‐Arkema, Rebecca; Ongstad, Emily L.; Koren, Michael; Hirshberg, Boaz (Journal of the American Heart Association, 2021)
Keywords: Administration, Intravenous; Adult; Aged; Apolipoprotein A-I - blood; atherosclerosis; cholesterol efflux capacity; cholesterol homeostasis; cholesterol reverse cholesterol transport; Coronary Disease - drug therapy; Dose-Response Relationship, Drug; Double-Blind Method; Female; high‐density lipoprotein cholesterol; Humans; Injections, Subcutaneous; Lipoproteins, HDL - administration & dosage; Lipoproteins, HDL - adverse effects; Lipoproteins, HDL - blood; Lipoproteins, LDL - administration & dosage; Lipoproteins, LDL - adverse effects; Lipoproteins, LDL - blood; Male; Middle Aged; Original Research; Phosphatidylcholine-Sterol O-Acyltransferase - administration & dosage; Phosphatidylcholine-Sterol O-Acyltransferase - adverse effects; Phosphatidylcholine-Sterol O-Acyltransferase - blood; Recombinant Proteins - administration & dosage; Recombinant Proteins - adverse effects; Recombinant Proteins - blood; Treatment Outcome; atherosclerosis; cholesterol reverse cholesterol transport; cholesterol homeostasis; cholesterol efflux capacity; high‐density lipoprotein cholesterol