Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment
MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Recently, circulating miRNAs have been reported as potential biomarkers for various pathologic conditions. The present stu...
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Published in | Journal of Alzheimer's disease Vol. 45; no. 3; p. 721 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Netherlands
01.01.2015
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Abstract | MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Recently, circulating miRNAs have been reported as potential biomarkers for various pathologic conditions. The present study was performed to investigate the potential role of circulating miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI). We collected 66 patients with MCI and 76 normal controls from our previous cross-sectional cohort study. Seven miRNAs (miR-206, miR-132, miR-193b, miR-130b, miR-20a, miR-296, and miR-329) related to Alzheimer's disease (AD) were detected in serum using a quantitative real-time PCR (qRT-PCR) method. Each miRNA's diagnostic performance was evaluated by receiver operating characteristic curves and the areas under curves (AUC) analysis. The levels of miR-206 and miR-132 in MCI patients' serum were significantly elevated compared to normal controls. Combining detection of miR-206 and miR-132 achieved the highest AUC of 0.981, followed by test of miR-206 (AUC = 0.880) and miR-132 (AUC = 0.912) separately. Importantly, miR-206 and miR-132 were respectively correlated with the Montreal Cognitive Assessment score in MCI patients. These results preliminarily indicated that circulating miR-206 and miR-132 as novel miRNAs upregulated in MCI patient were potential biomarkers for diagnosis of MCI. |
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AbstractList | MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Recently, circulating miRNAs have been reported as potential biomarkers for various pathologic conditions. The present study was performed to investigate the potential role of circulating miRNAs as diagnostic biomarkers for mild cognitive impairment (MCI). We collected 66 patients with MCI and 76 normal controls from our previous cross-sectional cohort study. Seven miRNAs (miR-206, miR-132, miR-193b, miR-130b, miR-20a, miR-296, and miR-329) related to Alzheimer's disease (AD) were detected in serum using a quantitative real-time PCR (qRT-PCR) method. Each miRNA's diagnostic performance was evaluated by receiver operating characteristic curves and the areas under curves (AUC) analysis. The levels of miR-206 and miR-132 in MCI patients' serum were significantly elevated compared to normal controls. Combining detection of miR-206 and miR-132 achieved the highest AUC of 0.981, followed by test of miR-206 (AUC = 0.880) and miR-132 (AUC = 0.912) separately. Importantly, miR-206 and miR-132 were respectively correlated with the Montreal Cognitive Assessment score in MCI patients. These results preliminarily indicated that circulating miR-206 and miR-132 as novel miRNAs upregulated in MCI patient were potential biomarkers for diagnosis of MCI. |
Author | Wang, Lan Xie, Bing Song, Mei Cui, Dongsheng Wang, Xueyi Liu, Zanchao Zhang, Qingfu Xu, Shunjiang Zhou, Huimin Zhang, Rui Yu, Lulu |
Author_xml | – sequence: 1 givenname: Bing surname: Xie fullname: Xie, Bing organization: Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China – sequence: 2 givenname: Huimin surname: Zhou fullname: Zhou, Huimin organization: Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China – sequence: 3 givenname: Rui surname: Zhang fullname: Zhang, Rui organization: Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China – sequence: 4 givenname: Mei surname: Song fullname: Song, Mei organization: Department of Mental Health, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China Institute of Mental Health, Hebei Medical University, Shijiazhuang, P.R. China – sequence: 5 givenname: Lulu surname: Yu fullname: Yu, Lulu organization: Department of Mental Health, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China Institute of Mental Health, Hebei Medical University, Shijiazhuang, P.R. China – sequence: 6 givenname: Lan surname: Wang fullname: Wang, Lan organization: Department of Mental Health, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China Institute of Mental Health, Hebei Medical University, Shijiazhuang, P.R. China – sequence: 7 givenname: Zanchao surname: Liu fullname: Liu, Zanchao organization: Department of Endocrinology, The Second Hospital of Shijiazhuang City, Shijiazhuang, P.R. China – sequence: 8 givenname: Qingfu surname: Zhang fullname: Zhang, Qingfu organization: Department of Burns and Plastic Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China – sequence: 9 givenname: Dongsheng surname: Cui fullname: Cui, Dongsheng organization: Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China – sequence: 10 givenname: Xueyi surname: Wang fullname: Wang, Xueyi organization: Department of Mental Health, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China Institute of Mental Health, Hebei Medical University, Shijiazhuang, P.R. China – sequence: 11 givenname: Shunjiang surname: Xu fullname: Xu, Shunjiang organization: Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, P.R. China |
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SubjectTerms | Aged Aged, 80 and over Biomarkers - blood Brain-Derived Neurotrophic Factor - blood Cognitive Dysfunction - blood Cohort Studies Fasting - blood Female Humans Male MicroRNAs - blood MicroRNAs - genetics Middle Aged RNA, Messenger - metabolism ROC Curve Sirtuin 1 - blood Statistics, Nonparametric Up-Regulation - physiology |
Title | Serum miR-206 and miR-132 as Potential Circulating Biomarkers for Mild Cognitive Impairment |
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