Hyperplasia of Smooth Muscle in Mild to Moderate Asthma without Changes in Cell Size or Gene Expression

• Published in: American journal of respiratory and critical care medicine Vol. 169; no. 9; pp. 1001 - 1006
• Main Authors: Woodruff, Prescott G, Dolganov, Gregory M, Ferrando, Ronald E, Donnelly, Samantha, Hays, Steven R, Solberg, Owen D, Carter, Roderick, Wong, Hofer H, Cadbury, Peggy S, Fahy, John V
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 01.05.2004; American Lung Association; American Thoracic Society
• Subjects: Adult; Airway management; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asthma; Asthma - genetics; Asthma - pathology; Asthma - physiopathology; Biological and medical sciences; Biopsy; Bronchial Hyperreactivity - pathology; Bronchial Hyperreactivity - physiopathology; Bronchoscopy; Case-Control Studies; Cell Division; Cell Size; Cross-Sectional Studies; Female; Forced Expiratory Volume; Gene expression; Gene Expression - physiology; Gene Expression Profiling; Genotype & phenotype; Humans; Hyperplasia; Hypertrophy; Intensive care medicine; Kinases; Laboratories; Lasers; Male; Medical sciences; Microdissection; Microscopy, Confocal; Middle Aged; Muscle, Smooth - pathology; Muscle, Smooth - physiopathology; Myocytes, Smooth Muscle - pathology; Phenotype; Polymerase Chain Reaction; Proteins; Severity of Illness Index; Smooth muscle; Spirometry; Lung disease; Intensive care; Respiratory disease; Hyperplasia; airway remodeling; airway smooth muscle; Smooth muscle; Gene expression; Asthma; Bronchus disease; Obstructive pulmonary disease; bronchial hyperresponsiveness; Resuscitation

Bronchial hyperresponsiveness in mild to moderate asthma may result from airway smooth muscle cell proliferation or acquisition of a hypercontractile phenotype. Because these cells have not been well characterized in mild to moderate asthma, we examined the morphometric and gene expression character...