Selective decrease of bis(monoacylglycero)phosphate content in macrophages by high supplementation with docosahexaenoic acid

• Published in: Journal of lipid research Vol. 50; no. 2; pp. 243 - 255
• Main Authors: Bouvier, Jérôme, Zemski Berry, Karin A, Hullin-Matsuda, Françoise, Makino, Asami, Michaud, Sabine, Geloën, Alain, Murphy, Robert C, Kobayashi, Toshihide, Lagarde, Michel, Delton-Vandenbroucke, Isabelle
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 01.02.2009
• Subjects: Animals; Cells, Cultured; Cholesterol - metabolism; Dietary Supplements; Docosahexaenoic Acids - administration & dosage; Docosahexaenoic Acids - pharmacology; Life Sciences; Liposomes - metabolism; Lysophospholipids - metabolism; Macrophages - metabolism; Mice; Monoglycerides - metabolism; Oxidation-Reduction; Phosphatidylglycerols - metabolism

Bis(monoacylglycero)phosphate (BMP) is a unique phospholipid (PL) preferentially found in late endosomal membranes, where it forms specialized lipid domains. Recently, using cultured macrophages treated with anti-BMP antibody, we showed that BMP-rich domains are involved in cholesterol homeostasis....