Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome - Lam, Yin‐Yu; Keung, Wendy; Chan, Chun‐Ho; Geng, Lin; Wong, Nicodemus; Brenière‐Letuffe, David; Li, Ronald A.; Cheung, Yiu‐Fai (Journal of the American Heart Association, 2020)
Keywords: Bioengineering; Heart Defects, Congenital - genetics; Heart Defects, Congenital - pathology; Heart Defects, Congenital - physiopathology; Humans; hypoplastic right heart syndrome; induced pluripotent stem cells; Induced Pluripotent Stem Cells - physiology; Models, Cardiovascular; Models, Genetic; Myocardial Contraction; Myocytes, Cardiac - physiology; Organ Culture Techniques; Original Research; Pulmonary Atresia - genetics; Pulmonary Atresia - pathology; Pulmonary Atresia - physiopathology; pulmonary atresia with intact ventricular septum; single cell transcriptomics; Tissue Engineering - methods; Transcriptome; hypoplastic right heart syndrome; induced pluripotent stem cells; single cell transcriptomics; pulmonary atresia with intact ventricular septum