Letrozole treatment alters hippocampal gene expression in common marmosets (Callithrix jacchus)

• Published in: Hormones and behavior Vol. 147; p. 105281
• Main Authors: Edwards, Mélise, Lam, Sam, Ranjan, Ravi, Pereira, Mariana, Babbitt, Courtney, Lacreuse, Agnès
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2023
• Subjects: Animals; Aromatase inhibitor; Aromatase Inhibitors - pharmacology; Callithrix; Estradiol; Estrone; Female; Gene Expression; Hippocampus; Letrozole; Letrozole - pharmacology; Male; Nitriles - pharmacology; RNA-sequencing; Triazoles - pharmacology; RNA-sequencing; Aromatase inhibitor; Estradiol; Letrozole; Hippocampus

Aromatase inhibitors (AIs) are a class of drugs commonly given to patients with estrogen receptor (ER)-dependent breast cancers to reduce estrogenic stimulation. However, AIs like Letrozole are associated with negative side effects such as cognitive deficits, sleep disturbances and hot flashes. We h...