Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis - Chen, Suwen; Wang, Yadong; Pan, Yamu; Liu, Yao; Zheng, Shuang; Ding, Ke; Mu, Kaiyu; Yuan, Ye; Li, Zhaoyang; Song, Hongxian; Jin, Ying; Fu, Jian (Journal of the American Heart Association, 2020)
Keywords: Animals; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; atherosclerosis; Atherosclerosis - metabolism; Atherosclerosis - pathology; Atherosclerosis - prevention & control; Disease Models, Animal; HEK293 Cells; Humans; inflammasome; Inflammasomes - metabolism; Inflammation Mediators - metabolism; Interleukin-1beta - metabolism; Macrophages - drug effects; Macrophages - metabolism; Mice, Knockout, ApoE; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; NLRP3 ubiquitination; Original Research; ortho-Aminobenzoates - pharmacology; Plaque, Atherosclerotic; Receptors, LDL - deficiency; Receptors, LDL - genetics; tranilast; Ubiquitination; vascular inflammation; Vasculitis - metabolism; Vasculitis - pathology; Vasculitis - prevention & control; atherosclerosis; tranilast; vascular inflammation; inflammasome; NLRP3 ubiquitination