Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages

• Published in: American journal of physiology. Renal physiology Vol. 288; no. 4; pp. F722 - F731
• Main Authors: Day, Yuan-Ji, Huang, Liping, Ye, Hong, Linden, Joel, Okusa, Mark D
• Format: Journal Article
• Language: English
• Published: United States 01.04.2005
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - immunology; Acute Kidney Injury - pathology; Adenosine A2 Receptor Agonists; Animals; Antimetabolites; Cell Line; Clodronic Acid; Cyclohexanecarboxylic Acids - pharmacology; Cytokines - genetics; Humans; Kidney - immunology; Kidney - pathology; Liposomes; Macrophages - cytology; Macrophages - immunology; Macrophages - metabolism; Mice; Mice, Inbred C57BL; Purines - pharmacology; Receptor, Adenosine A2A - genetics; Receptor, Adenosine A2A - metabolism; Reperfusion Injury - chemically induced; Reperfusion Injury - immunology; Reperfusion Injury - pathology; RNA, Messenger - analysis; Transfection

The role of monocytes/macrophages in the pathogenesis of ischemia-reperfusion injury (IRI) is unknown. We sought to determine whether activation of macrophage adenosine 2A (A(2A)) receptors (A(2A)Rs) mediates tissue protection. We subjected C57Bl/6 mice infused with clodronate [dichloromethylene bis...