FcGBP and VCAM-1 are ponderable biomarkers for differential diagnosis of alcoholic liver cirrhosis

• Published in: Drug and alcohol dependence Vol. 233; p. 109377
• Main Authors: Abassa, Kodjo-Kunale, Xiao, Xiu-Ping, Zhou, Hao-Xiong, Wu, Xiao-Ying, Guo, Yun-Wei, Wu, Bin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2022; Elsevier Science Ltd
• Subjects: Alcohol use; Alcoholic liver cirrhosis; Biological markers; Biomarkers; Cell Adhesion Molecules; Cirrhosis; Coexisting; Diagnosis; Diagnosis, Differential; Differential diagnosis; Discrimination; Hepatitis B; Humans; Liver; Liver cirrhosis; Liver Cirrhosis, Alcoholic - diagnosis; Mass spectrometry; Mass spectroscopy; Medical diagnosis; Proteins; Proteomic; Proteomics; Sensitivity; Serum; Spectrometry; Vascular Cell Adhesion Molecule-1; FcGBP; VCAM-1; NPV; PPV; Proteomic; Biomarkers; AUROC; Coexisting; Alcoholic liver cirrhosis; Hepatitis B

Early diagnosis of alcoholic liver cirrhosis (ALD) and coexisting ALD and hepatitis B virus-induced cirrhosis (ALD+HBV) is primordial for an optimal management of these conditions. However, the lack of specific noninvasive biomarkers coupled with the inaccuracy of self-reported alcohol consumption m...