Nasal exudate for diagnosis of stroke: fundamental studies through iron fractionation, total iron, and targeted protein determinations

• Published in: Analytical and bioanalytical chemistry Vol. 416; no. 24; pp. 5365 - 5375
• Main Authors: Marina-Latorre, Marta, Lobo, Lara, García-Cabo, Carmen, Benavente-Fernández, Lorena, Calleja-Puerta, Sergio, Fernández-Abedul, M. Teresa, González-Iglesias, Héctor, Pereiro, Rosario
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2024; Springer Nature B.V
• Subjects: Aged; Analytical Chemistry; Biochemistry; Biological analysis; Brain research; Cation Transport Proteins; Characterization and Evaluation of Materials; Chemical Fractionation - methods; Chemistry; Chemistry and Materials Science; Chromatography; Column chromatography; Diagnosis; Dilution; Enzyme-Linked Immunosorbent Assay - methods; Exudates and Transudates - chemistry; Exudation; Female; Ferritin; Ferritins - analysis; Food Science; Fractionation; gel chromatography; Hemorrhage; Human subjects; Humans; Inductively coupled plasma; Iron; Iron - analysis; Ischemia; isotope dilution technique; Laboratory Medicine; Lactoferrin; Lactoferrin - analysis; Male; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Metabolism; Middle Aged; Monitoring/Environmental Analysis; nose; Proteins; Radiochemical analysis; Research Paper; Sampling; Scientific imaging; Signal transduction; Size exclusion chromatography; spectroscopy; Stroke; Stroke - diagnosis; Tomography; Transferrin; Transferrin - analysis; Nasal exudate; Size exclusion chromatography; Isotope dilution analysis; Stroke; Elemental analysis; HPLC-ICP-MS

During the last years, there has been an increasing research interest in the analysis of biological fluids requiring non-invasive sampling for biomedical and clinical applications. In this work, we have focused on the nasal exudate with the aim of investigating the potential use of this fluid to kno...