IFN-γ-independent IgG2a production in mice infected with viruses and parasites
After infection with some viruses and intracellular parasites, antibody production is restricted to IgG2a. We first observed that, whereas live viruses such as lactate dehydrogenase-elevating virus (LDV) or mouse adenovirus induced mostly an IgG2a response, a large proportion of antibodies produced...
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| Published in | International immunology Vol. 12; no. 2; pp. 223 - 230 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
01.02.2000
Oxford Publishing Limited (England) |
| Subjects | |
| Online Access | Get full text |
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| Abstract | After infection with some viruses and intracellular parasites, antibody production is restricted to IgG2a. We first observed that, whereas live viruses such as lactate dehydrogenase-elevating virus (LDV) or mouse adenovirus induced mostly an IgG2a response, a large proportion of antibodies produced against killed viruses were IgG1. This IgG1 antiviral response was suppressed when live virions were added to inactivated viral particles. These results indicate that the IgG2a preponderance is related to the infectious process itself rather than to the type of antigen involved. Since IFN-γ is known to stimulate IgG2a production by activated B lymphocytes and to be secreted after infection, we examined the role of this cytokine in the antibody isotypic distribution caused by LDV. Most IgG2a responses were relatively unaffected in mice deficient for the IFN-γ receptor or treated with anti-IFN-γ antibody. A similar IFN-γ-independent IgG2a secretion was observed after infection with the parasites Toxoplasma gondii and Trypanosoma cruzi. However, the IFN-γ-independent IgG2a production triggered by infection still required the presence of functional Th lymphocytes. Therefore, signal(s) other than IFN-γ secretion may explain the Th-dependent isotypic bias in antibody secretion triggered by viruses and parasites. |
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| AbstractList | After infection with some viruses and intracellular parasites, antibody production is restricted to IgG2a. We first observed that, whereas live viruses such as lactate dehydrogenase-elevating virus (LDV) or mouse adenovirus induced mostly an IgG2a response, a large proportion of antibodies produced against killed viruses were IgG1. This IgG1 antiviral response was suppressed when live virions were added to inactivated viral particles. These results indicate that the IgG2a preponderance is related to the infectious process itself rather than to the type of antigen involved. Since IFN-γ is known to stimulate IgG2a production by activated B lymphocytes and to be secreted after infection, we examined the role of this cytokine in the antibody isotypic distribution caused by LDV. Most IgG2a responses were relatively unaffected in mice deficient for the IFN-γ receptor or treated with anti-IFN-γ antibody. A similar IFN-γ-independent IgG2a secretion was observed after infection with the parasites Toxoplasma gondii and Trypanosoma cruzi. However, the IFN-γ-independent IgG2a production triggered by infection still required the presence of functional Th lymphocytes. Therefore, signal(s) other than IFN-γ secretion may explain the Th-dependent isotypic bias in antibody secretion triggered by viruses and parasites. After infection with some viruses and intracellular parasites, antibody production is restricted to IgG2a. We first observed that, whereas live viruses such as lactate dehydrogenase-elevating virus (LDV) or mouse adenovirus induced mostly an IgG2a response, a large proportion of antibodies produced against killed viruses were IgG1. This IgG1 antiviral response was suppressed when live virions were added to inactivated viral particles. These results indicate that the IgG2a preponderance is related to the infectious process itself rather than to the type of antigen involved. Since IFN-gamma is known to stimulate IgG2a production by activated B lymphocytes and to be secreted after infection, we examined the role of this cytokine in the antibody isotypic distribution caused by LDV. Most IgG2a responses were relatively unaffected in mice deficient for the IFN-gamma receptor or treated with anti-IFN-gamma antibody. A similar IFN-gamma-independent IgG2a secretion was observed after infection with the parasites Toxoplasma gondii and Trypanosoma cruzi. However, the IFN-gamma-independent IgG2a production triggered by infection still required the presence of functional T(h) lymphocytes. Therefore, signal(s) other than IFN-gamma secretion may explain the T(h)-dependent isotypic bias in antibody secretion triggered by viruses and parasites. After infection with some viruses and intracellular parasites, antibody production is restricted to IgG2a. We first observed that, whereas live viruses such as lactate dehydrogenase-elevating virus (LDV) or mouse adenovirus induced mostly an IgG2a response, a large proportion of antibodies produced against killed viruses were IgG1. This IgG1 antiviral response was suppressed when live virions were added to inactivated viral particles. These results indicate that the IgG2a preponderance is related to the infectious process itself rather than to the type of antigen involved. Since IFN- gamma is known to stimulate IgG2a production by activated B lymphocytes and to be secreted after infection, we examined the role of this cytokine in the antibody isotypic distribution caused by LDV. Most IgG2a responses were relatively unaffected in mice deficient for the IFN- gamma receptor or treated with anti-IFN- gamma antibody. A similar IFN- gamma -independent IgG2a secretion was observed after infection with the parasites Toxoplasma gondii and Trypanosoma cruzi. However, the IFN- gamma -independent IgG2a production triggered by infection still required the presence of functional T sub(h) lymphocytes. Therefore, signal(s) other than IFN- gamma secretion may explain the T sub(h)-dependent isotypic bias in antibody secretion triggered by viruses and parasites. |
| Author | Heessen, Frans W. A. Carlier, Yves Truyens, Carine Coutelier, Jean-Paul Markine-Goriaynoff, Dominique Bigaignon, Geoffroy van der Logt, Jos T.M. Nguyen, Trung D. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10653858$$D View this record in MEDLINE/PubMed |
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| Snippet | After infection with some viruses and intracellular parasites, antibody production is restricted to IgG2a. We first observed that, whereas live viruses such as... |
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| SubjectTerms | Adenoviridae - immunology Adenoviridae Infections - immunology Adenovirus Animals Antibodies, Protozoan - biosynthesis Antibodies, Protozoan - blood Antibodies, Viral - biosynthesis Antibodies, Viral - blood antibody isotype Arterivirus Infections - immunology Chagas Disease - immunology cytokine Female g-Interferon Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin G2a Interferon-gamma - pharmacology KLH keyhole limpet hemocyanin lactate dehydrogenase-elevating virus Lactate dehydrogenase-elevating virus - immunology LDH lactate dehydrogenase LDV lactate dehydrogenase-elevating virus MAV mouse adenovirus Mice Mice, Inbred CBA Murine adenovirus 1 Protozoan Infections - immunology Spleen - immunology Toxoplasma - immunology Toxoplasma gondii Toxoplasmosis, Animal - immunology Trypanosoma cruzi Virus Diseases - immunology |
| Title | IFN-γ-independent IgG2a production in mice infected with viruses and parasites |
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