Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6)

• Published in: Biochemical pharmacology Vol. 81; no. 7; pp. 942 - 949
• Main Authors: Wong, Chi Chun, Botting, Nigel P., Orfila, Caroline, Al-Maharik, Nawaf, Williamson, Gary
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.04.2011; Elsevier
• Subjects: Adenine - analogs & derivatives; Adenine - pharmacology; Antiviral Agents - pharmacology; Bioavailability; Biological and medical sciences; Cell Line; Chromatography, High Pressure Liquid; Flavonoids - pharmacology; Food–drug interaction; Humans; Isoflavones; Kinetics; Life Sciences; Medical sciences; Organic Anion Transport Protein 1 - metabolism; Organic anion transporters; Organophosphonates - pharmacology; Pharmaceutical sciences; Pharmacology; Pharmacology. Drug treatments; Quercetin; BCRP; Organic anion transporters; OAT; Quercetin; MRP; Bioavailability; Food–drug interaction; Isoflavones; RNA-directed DNA polymerase; Cytotoxicity; Nucleotide analog; Isoflavone derivatives; Flavonoid; Food drug interaction; Phytoestrogen; Polyphenol; Reverse transcriptase inhibitor; Organic anion transporter; Nucleoside analog; Antiviral; Food-drug interaction; Isoflavone; Purine nucleotide; Acyclic nucleotide; Enzyme; Transferases; Enzyme inhibitor; Organic phosphonate; Organic anion transporter OAT1; Nucleotidyltransferases; Adefovir; Phenols; Conjugated compound; Pharmacokinetics; quercetin; food-drug interaction; isoflavones; bioavailability; organic anion transporters

Flavonoids are conjugated by phase II enzymes in humans to form glucuronidated and sulfated metabolites that are excreted in urine via the kidney. In this study, we examined the interaction between metabolites of quercetin and isoflavonoids found in vivo with human organic anion transporters 1 (OAT1...