Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer’s Disease

• Published in: International journal of molecular sciences Vol. 22; no. 24; p. 13260
• Main Authors: Barabás, Klaudia, Kobolák, Julianna, Godó, Soma, Kovács, Tamás, Ernszt, Dávid, Kecskés, Miklós, Varga, Csaba, Jánosi, Tibor Z., Fujiwara, Takahiro, Kusumi, Akihiro, Téglási, Annamária, Dinnyés, András, Ábrahám, István M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.12.2021; MDPI
• Subjects: Adult; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Animals; Cell Survival; Cells, Cultured; Experiments; Female; Growth factors; Humans; Induced Pluripotent Stem Cells - cytology; Induced Pluripotent Stem Cells - metabolism; Male; Middle Aged; Mutation; Nerve Tissue Proteins - metabolism; Neurons; Neurons - cytology; Neurons - metabolism; PC12 Cells; Presenilin-1 - genetics; Proteins; Rats; Receptor, trkA - metabolism; Receptors, Nerve Growth Factor - metabolism; Signal Transduction; Single Molecule Imaging; p75NTR; TrkA; Alzheimer’s disease; neuronal; receptor dynamics; live-cell single-molecule imaging; human-induced pluripotent stem cell

Neurotrophin receptors such as the tropomyosin receptor kinase A receptor (TrkA) and the low-affinity binding p75 neurotrophin receptor p75NTR play a critical role in neuronal survival and their functions are altered in Alzheimer’s disease (AD). Changes in the dynamics of receptors on the plasma mem...