Spironolactone Reduces Aortic Stiffness in Patients With Resistant Hypertension Independent of Blood Pressure Change

• Published in: Journal of the American Heart Association Vol. 10; no. 17; p. e019434
• Main Authors: Aryal, Sudeep R, Siddiqui, Mohammed, Sharifov, Oleg F, Coffin, Megan D, Zhang, Bin, Gaddam, Krishna K, Gupta, Himanshu, Denney, Jr, Thomas S, Dell'Italia, Louis J, Oparil, Suzanne, Calhoun, David A, Lloyd, Steven G
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 07.09.2021; Wiley
• Subjects: Antihypertensive Agents - therapeutic use; aorta; Blood Pressure - drug effects; Humans; hyperaldosteronism; Hypertension - diagnosis; Hypertension - drug therapy; Original Research; Pulse Wave Analysis; resistant hypertension; spironolactone; Spironolactone - therapeutic use; Vascular Stiffness - drug effects; hyperaldosteronism; aorta; resistant hypertension; spironolactone

Background Aortic stiffness is an independent predictor of cardiovascular events in patients with arterial hypertension. Resistant hypertension is often linked to hyperaldosteronism and associated with adverse outcomes. Spironolactone, a mineralocorticoid receptor antagonist, has been shown to reduc...