Humans and Mice Display Opposing Patterns of “Browning” Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots

• Published in: Frontiers in cardiovascular medicine Vol. 4; p. 27
• Main Authors: Zuriaga, Maria A., Fuster, Jose J., Gokce, Noyan, Walsh, Kenneth
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.05.2017
• Subjects: adipose tissue; browning; Cardiovascular Medicine; gene expression; human; mouse; adipose tissue; browning; mouse; human; gene expression

Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new...