Humans and Mice Display Opposing Patterns of “Browning” Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots
Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new...
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| Published in | Frontiers in cardiovascular medicine Vol. 4; p. 27 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
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Switzerland
Frontiers Media S.A
05.05.2017
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| Online Access | Get full text |
| ISSN | 2297-055X 2297-055X |
| DOI | 10.3389/fcvm.2017.00027 |
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| Abstract | Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology. |
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| AbstractList | Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology.Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology. Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology. |
| Author | Zuriaga, Maria A. Fuster, Jose J. Walsh, Kenneth Gokce, Noyan |
| AuthorAffiliation | 1 Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine , Boston, MA , USA 2 Cardiovascular Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine , Boston, MA , USA |
| AuthorAffiliation_xml | – name: 1 Molecular Cardiology, Whitaker Cardiovascular Institute, Boston University School of Medicine , Boston, MA , USA – name: 2 Cardiovascular Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine , Boston, MA , USA |
| Author_xml | – sequence: 1 givenname: Maria A. surname: Zuriaga fullname: Zuriaga, Maria A. – sequence: 2 givenname: Jose J. surname: Fuster fullname: Fuster, Jose J. – sequence: 3 givenname: Noyan surname: Gokce fullname: Gokce, Noyan – sequence: 4 givenname: Kenneth surname: Walsh fullname: Walsh, Kenneth |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28529941$$D View this record in MEDLINE/PubMed |
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| Copyright | Copyright © 2017 Zuriaga, Fuster, Gokce and Walsh. 2017 Zuriaga, Fuster, Gokce and Walsh |
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| Keywords | adipose tissue browning mouse human gene expression |
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| Title | Humans and Mice Display Opposing Patterns of “Browning” Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots |
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