Endocrine gland-derived vascular endothelial growth factor modulates proliferation, apoptosis and migration in pancreatic cancer cells

• Published in: Molecular medicine reports Vol. 11; no. 6; pp. 4279 - 4284
• Main Authors: REN, LINAN, GUO, XIAOZHONG, SHAO, XIAODONG, LI, HONGYU, YAO, HUI
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.06.2015; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adult; Aged; Amino acids; Apoptosis; Apoptosis - drug effects; Biosynthesis; Cancer cells; Cancer therapies; Cell growth; Cell Line, Tumor; Cell Movement - drug effects; Cell proliferation; Cell Proliferation - drug effects; Development and progression; endocrine gland-derived vascular endothelial growth factor; Endothelium; Female; Gene Expression; Health aspects; Humans; Immunohistochemistry; Male; Males; MAP kinase; MAP Kinase Signaling System - drug effects; Medical prognosis; Middle Aged; Mortality; Neoplasm Staging; Pancreatic cancer; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Phosphorylation; Physiological aspects; proliferation; Protein kinase; Proteins; Studies; Survival factor; Tumor cell lines; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - genetics; Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - metabolism; Vascular Endothelial Growth Factor, Endocrine-Gland-Derived - pharmacology; China; United States > US

Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is a newly cloned factor that selectively acts on the endothelium of endocrine gland cells. EG-VEGF was previously identified as an important cytokine, involved in the modulation of apoptosis in pancreatic cancer cell lines. The pr...