STAT-3 activation is necessary for ischemic preconditioning in hypertrophied myocardium
Departments of 1 Surgery and 2 Medicine, University of Cincinnati, Cincinnati, Ohio; and 3 Harvard Medical School, Department of Medicine, and 4 Gwathmey, Incorporated, Boston, Massachusetts Submitted 19 December 2005 ; accepted in final form 9 March 2006 The JAK-STAT pathway is activated in the ear...
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Published in | American journal of physiology. Heart and circulatory physiology Vol. 291; no. 2; pp. H797 - H803 |
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01.08.2006
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Abstract | Departments of 1 Surgery and 2 Medicine, University of Cincinnati, Cincinnati, Ohio; and 3 Harvard Medical School, Department of Medicine, and 4 Gwathmey, Incorporated, Boston, Massachusetts
Submitted 19 December 2005
; accepted in final form 9 March 2006
The JAK-STAT pathway is activated in the early and late phases of ischemic preconditioning (IPC) in normal myocardium. The role of this pathway and the efficacy of IPC in hypertrophied hearts remain largely unknown. We hypothesized that phosphorylated STAT-3 (pSTAT-3) is necessary for effective IPC in pressure-overload hypertrophy. Male Sprague-Dawley rats 8 wk after thoracic aortic constriction (TAC) or sham operation underwent echocardiography and Langendorff perfusion. Randomized hearts were subjected to 30 min of global ischemia and 120 min of reperfusion with or without IPC in the presence or absence of the JAK-2 inhibitor AG-490 (AG). Functional recovery and STAT activation were assessed. TAC rats had a 31% increase in left ventricular mass (1,347 ± 58 vs. 1,028 ± 43 mg, TAC vs. sham, P < 0.001), increased anterior and posterior wall thickness but no difference in ejection fraction compared with sham-operated rats. In TAC, IPC improved end-reperfusion maximum first derivative of developed pressure (+dP/d t max ; 4,648 ± 309 vs. 2,737 ± 343 mmHg/s, IPC vs. non-IPC, P < 0.05) and minimum dP/d t (dP/d t min ; 2,239 ± 205 vs. 1,215 ± 149 mmHg/s, IPC vs. non-IPC, P < 0.05). IPC increased nuclear pSTAT-1 and pSTAT-3 in sham-operated rats but only pSTAT-3 in TAC. AG in TAC significantly attenuated +dP/d t max (4,648 ± 309 vs. 3,241 ± 420 mmHg/s, IPC vs. IPC + AG, P < 0.05) and dP/d t min (2,239 ± 205 vs. 1,323 ± 85 mmHg/s, IPC vs. IPC + AG, P < 0.05) and decreased only nuclear pSTAT-3. In myocardial hypertrophy, JAK-STAT signaling is important in IPC and exhibits a pattern of STAT activation distinct from nonhypertrophied myocardium. Limiting STAT-3 activation attenuates the efficacy of IPC in hypertrophy.
ischemia-reperfusion; Janus-activated kinase; signal transducer and activator of transcription; cardiac preconditioning; myocardial hypertrophy
Address for reprint requests and other correspondence: K. L. Butler, Univ. of Cincinnati, Dept. of Surgery, Division of Trauma/Critical Care, Inst. of Molecular Pharmacology & Biophysics, 231 Albert B. Sabin Way, Cincinnati, OH 45267-0828 (e-mail: karyn.butler{at}uc.edu ) |
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AbstractList | The JAK-STAT pathway is activated in the early and late phases of ischemic preconditioning (IPC) in normal myocardium. The role of this pathway and the efficacy of IPC in hypertrophied hearts remain largely unknown. We hypothesized that phosphorylated STAT-3 (pSTAT-3) is necessary for effective IPC in pressure-overload hypertrophy. Male Sprague-Dawley rats 8 wk after thoracic aortic constriction (TAC) or sham operation underwent echocardiography and Langendorff perfusion. Randomized hearts were subjected to 30 min of global ischemia and 120 min of reperfusion with or without IPC in the presence or absence of the JAK-2 inhibitor AG-490 (AG). Functional recovery and STAT activation were assessed. TAC rats had a 31% increase in left ventricular mass (1,347 ± 58 vs. 1,028 ± 43 mg, TAC vs. sham, P < 0.001), increased anterior and posterior wall thickness but no difference in ejection fraction compared with sham-operated rats. In TAC, IPC improved end-reperfusion maximum first derivative of developed pressure (+dP/d t
max
; 4,648 ± 309 vs. 2,737 ± 343 mmHg/s, IPC vs. non-IPC, P < 0.05) and minimum −dP/d t (−dP/d t
min
; −2,239 ± 205 vs. −1,215 ± 149 mmHg/s, IPC vs. non-IPC, P < 0.05). IPC increased nuclear pSTAT-1 and pSTAT-3 in sham-operated rats but only pSTAT-3 in TAC. AG in TAC significantly attenuated +dP/d t
max
(4,648 ± 309 vs. 3,241 ± 420 mmHg/s, IPC vs. IPC + AG, P < 0.05) and −dP/d t
min
(−2,239 ± 205 vs. −1,323 ± 85 mmHg/s, IPC vs. IPC + AG, P < 0.05) and decreased only nuclear pSTAT-3. In myocardial hypertrophy, JAK-STAT signaling is important in IPC and exhibits a pattern of STAT activation distinct from nonhypertrophied myocardium. Limiting STAT-3 activation attenuates the efficacy of IPC in hypertrophy. The JAK-STAT pathway is activated in the early and late phases of ischemic preconditioning (IPC) in normal myocardium. The role of this pathway and the efficacy of IPC in hypertrophied hearts remain largely unknown. We hypothesized that phosphorylated STAT-3 (pSTAT-3) is necessary for effective IPC in pressure-overload hypertrophy. Male Sprague-Dawley rats 8 wk after thoracic aortic constriction (TAC) or sham operation underwent echocardiography and Langendorff perfusion. Randomized hearts were subjected to 30 min of global ischemia and 120 min of reperfusion with or without IPC in the presence or absence of the JAK-2 inhibitor AG-490 (AG). Functional recovery and STAT activation were assessed. TAC rats had a 31% increase in left ventricular mass (1,347 +/- 58 vs. 1,028 +/- 43 mg, TAC vs. sham, P < 0.001), increased anterior and posterior wall thickness but no difference in ejection fraction compared with sham-operated rats. In TAC, IPC improved end-reperfusion maximum first derivative of developed pressure (+dP/dt(max); 4,648 +/- 309 vs. 2,737 +/- 343 mmHg/s, IPC vs. non-IPC, P < 0.05) and minimum -dP/dt (-dP/dt(min); -2,239 +/- 205 vs. -1,215 +/- 149 mmHg/s, IPC vs. non-IPC, P < 0.05). IPC increased nuclear pSTAT-1 and pSTAT-3 in sham-operated rats but only pSTAT-3 in TAC. AG in TAC significantly attenuated +dP/dt(max) (4,648 +/- 309 vs. 3,241 +/- 420 mmHg/s, IPC vs. IPC + AG, P < 0.05) and -dP/dt(min) (-2,239 +/- 205 vs. -1,323 +/- 85 mmHg/s, IPC vs. IPC + AG, P < 0.05) and decreased only nuclear pSTAT-3. In myocardial hypertrophy, JAK-STAT signaling is important in IPC and exhibits a pattern of STAT activation distinct from nonhypertrophied myocardium. Limiting STAT-3 activation attenuates the efficacy of IPC in hypertrophy. Departments of 1 Surgery and 2 Medicine, University of Cincinnati, Cincinnati, Ohio; and 3 Harvard Medical School, Department of Medicine, and 4 Gwathmey, Incorporated, Boston, Massachusetts Submitted 19 December 2005 ; accepted in final form 9 March 2006 The JAK-STAT pathway is activated in the early and late phases of ischemic preconditioning (IPC) in normal myocardium. The role of this pathway and the efficacy of IPC in hypertrophied hearts remain largely unknown. We hypothesized that phosphorylated STAT-3 (pSTAT-3) is necessary for effective IPC in pressure-overload hypertrophy. Male Sprague-Dawley rats 8 wk after thoracic aortic constriction (TAC) or sham operation underwent echocardiography and Langendorff perfusion. Randomized hearts were subjected to 30 min of global ischemia and 120 min of reperfusion with or without IPC in the presence or absence of the JAK-2 inhibitor AG-490 (AG). Functional recovery and STAT activation were assessed. TAC rats had a 31% increase in left ventricular mass (1,347 ± 58 vs. 1,028 ± 43 mg, TAC vs. sham, P < 0.001), increased anterior and posterior wall thickness but no difference in ejection fraction compared with sham-operated rats. In TAC, IPC improved end-reperfusion maximum first derivative of developed pressure (+dP/d t max ; 4,648 ± 309 vs. 2,737 ± 343 mmHg/s, IPC vs. non-IPC, P < 0.05) and minimum dP/d t (dP/d t min ; 2,239 ± 205 vs. 1,215 ± 149 mmHg/s, IPC vs. non-IPC, P < 0.05). IPC increased nuclear pSTAT-1 and pSTAT-3 in sham-operated rats but only pSTAT-3 in TAC. AG in TAC significantly attenuated +dP/d t max (4,648 ± 309 vs. 3,241 ± 420 mmHg/s, IPC vs. IPC + AG, P < 0.05) and dP/d t min (2,239 ± 205 vs. 1,323 ± 85 mmHg/s, IPC vs. IPC + AG, P < 0.05) and decreased only nuclear pSTAT-3. In myocardial hypertrophy, JAK-STAT signaling is important in IPC and exhibits a pattern of STAT activation distinct from nonhypertrophied myocardium. Limiting STAT-3 activation attenuates the efficacy of IPC in hypertrophy. ischemia-reperfusion; Janus-activated kinase; signal transducer and activator of transcription; cardiac preconditioning; myocardial hypertrophy Address for reprint requests and other correspondence: K. L. Butler, Univ. of Cincinnati, Dept. of Surgery, Division of Trauma/Critical Care, Inst. of Molecular Pharmacology & Biophysics, 231 Albert B. Sabin Way, Cincinnati, OH 45267-0828 (e-mail: karyn.butler{at}uc.edu ) |
Author | Gwathmey, Judith K Huffman, Lynn C Koch, Sheryl E Hahn, Harvey S Butler, Karyn L |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16565302$$D View this record in MEDLINE/PubMed |
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Snippet | Departments of 1 Surgery and 2 Medicine, University of Cincinnati, Cincinnati, Ohio; and 3 Harvard Medical School, Department of Medicine, and 4 Gwathmey,... The JAK-STAT pathway is activated in the early and late phases of ischemic preconditioning (IPC) in normal myocardium. The role of this pathway and the... |
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SubjectTerms | Animals Aorta, Thoracic - physiology Biotransformation - physiology Blotting, Western Cardiomegaly - physiopathology Echocardiography Hemodynamics - physiology In Vitro Techniques Ischemic Preconditioning, Myocardial Male Muscle Contraction - physiology Muscle Proteins - biosynthesis Muscle Proteins - genetics Muscle, Smooth, Vascular - physiology Myocardium - metabolism Perfusion Rats Rats, Sprague-Dawley STAT3 Transcription Factor - metabolism |
Title | STAT-3 activation is necessary for ischemic preconditioning in hypertrophied myocardium |
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