Aurora kinase A expression in pleomorphic adenoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma of salivary glands: an immunohistochemical study

• Published in: BMC oral health Vol. 25; no. 1; pp. 89 - 8
• Main Authors: Zare, Razieh, Izadi, Leila, Alarcón-Sánchez, Mario Alberto, Taghva, Masumeh, Ranjbar, Mohammad Ali
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.01.2025; BioMed Central; BMC
• Subjects: Adenoid; Adenoid cystic carcinoma; Adenoma; Adenoma, Pleomorphic - enzymology; Adenoma, Pleomorphic - pathology; Adolescent; Adult; Aged; Aurora kinase; Aurora kinase A; Aurora Kinase A - metabolism; Cancer; Carcinoma; Carcinoma, Adenoid Cystic - enzymology; Carcinoma, Adenoid Cystic - pathology; Carcinoma, Mucoepidermoid - enzymology; Carcinoma, Mucoepidermoid - pathology; Cell cycle; Cross-Sectional Studies; Dentistry; Diagnosis; Diagnostic immunohistochemistry; Exocrine glands; Female; Health aspects; Humans; Immunohistochemistry; Kinases; Male; Measurement; Medical diagnosis; Medical prognosis; Metastasis; Methods; Middle Aged; Mitosis; Mucoepidermoid carcinoma; Normal distribution; Oral cancer; Pleomorphic adenoma; Protein kinases; Proteins; Retrospective Studies; Salivary gland; Salivary Gland Neoplasms - enzymology; Salivary Gland Neoplasms - pathology; Salivary gland tumors; Statistical analysis; Tumors; Iran; Immunohistochemistry; Aurora kinase A; Pleomorphic adenoma; Adenoid cystic carcinoma; Mucoepidermoid carcinoma

Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. The aim of the present study was to evaluate the expression pattern of AurkA in the most common benign and mali...