Chronic Experimental Model of TNBS-Induced Colitis to Study Inflammatory Bowel Disease

• Published in: International journal of molecular sciences Vol. 23; no. 9; p. 4739
• Main Authors: Silva, Inês, Solas, João, Pinto, Rui, Mateus, Vanessa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.04.2022; MDPI
• Subjects: Animals; chronic animal model; Chronic Disease; Chronic illnesses; Colitis; Colitis - chemically induced; Colitis - pathology; Colon - pathology; Cytokines; Disease Models, Animal; Ethanol; Ethanol - pharmacology; Feces; Female; Hemoglobin; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - chemically induced; Inflammatory Bowel Diseases - pathology; Intestine; Mice; Morbidity; Mortality; Motility; Sulfonic acid; Survival; TNBS-induced colitis; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha - pharmacology; Tumor necrosis factor-TNF; Tumor necrosis factor-α; TNBS-induced colitis; chronic animal model; inflammatory bowel disease

Background: Inflammatory bowel disease (IBD) is a world healthcare problem. In order to evaluate the effect of new pharmacological approaches for IBD, we aim to develop and validate chronic trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. Methods: Experimental colitis was induced by the...