Impact of trastuzumab on wound healing in experimental glaucoma surgery
Background To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery. Design Comparative, experimental study. Samples Twenty eight eyes. Methods Twenty‐eight male New Zealand white rabbits were randomly assigned to four grou...
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| Published in | Clinical & experimental ophthalmology Vol. 43; no. 1; pp. 67 - 76 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Australia
Blackwell Publishing Ltd
01.01.2015
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Background
To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery.
Design
Comparative, experimental study.
Samples
Twenty eight eyes.
Methods
Twenty‐eight male New Zealand white rabbits were randomly assigned to four groups, each including seven rabbits: The rabbits in the control group were not operated on and did not receive any treatment. The rabbits in the sham group underwent trabeculectomy and had one drop of saline instilled four times a day for 14 days. The rabbits in the mitomycin‐C group underwent trabeculectomy, and a sponge soaked in 0.4 mg/mL mitomycin‐C was applied intraoperatively to the scleral surgical site for 3 min. The rabbits in the trastuzumab group underwent trabeculectomy and were injected subconjunctivally once with 1.2 mg/0.1 mL of the drug. On day 14 of the experiment, the operated and control eyes were enucleated and immunohistochemically analyzed.
Main Outcome Measures
Mean values of fibroblast, mononuclear cell and immunostaining intensities of the transforming growth factor‐β, fibroblast growth factor‐β, and platelet derived growth factor.
Results
The mean cell numbers and immunostaining intensities in the sham group were higher than those of the control group (P < 0.01). The mean cell numbers and immunostaining intensities in the mitomycin‐C group and trastuzumab group were statistically significantly lower than those of the sham group (P < 0.01) while mean cell numbers and immunostaining intensities in the mitomycin‐C group and trastuzumab group were similar (P > 0.05).
Conclusion
Subconjunctival trastuzumab injection effectively suppressed subconjunctival scarring after experimental glaucoma filtration surgery. |
|---|---|
| AbstractList | Abstract
Background
To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery.
Design
Comparative, experimental study.
Samples
Twenty eight eyes.
Methods
Twenty‐eight male
N
ew
Z
ealand white rabbits were randomly assigned to four groups, each including seven rabbits: The rabbits in the control group were not operated on and did not receive any treatment. The rabbits in the sham group underwent trabeculectomy and had one drop of saline instilled four times a day for 14 days. The rabbits in the mitomycin‐
C
group underwent trabeculectomy, and a sponge soaked in 0.4 mg/mL mitomycin‐
C
was applied intraoperatively to the scleral surgical site for 3 min. The rabbits in the trastuzumab group underwent trabeculectomy and were injected subconjunctivally once with 1.2 mg/0.1 mL of the drug. On day 14 of the experiment, the operated and control eyes were enucleated and immunohistochemically analyzed.
Main Outcome Measures
Mean values of fibroblast, mononuclear cell and immunostaining intensities of the transforming growth factor‐β, fibroblast growth factor‐β, and platelet derived growth factor.
Results
The mean cell numbers and immunostaining intensities in the sham group were higher than those of the control group (
P
< 0.01). The mean cell numbers and immunostaining intensities in the mitomycin‐
C
group and trastuzumab group were statistically significantly lower than those of the sham group (
P
< 0.01) while mean cell numbers and immunostaining intensities in the mitomycin‐
C
group and trastuzumab group were similar (
P
> 0.05).
Conclusion
Subconjunctival trastuzumab injection effectively suppressed subconjunctival scarring after experimental glaucoma filtration surgery. Background To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery. Design Comparative, experimental study. Samples Twenty eight eyes. Methods Twenty-eight male New Zealand white rabbits were randomly assigned to four groups, each including seven rabbits: The rabbits in the control group were not operated on and did not receive any treatment. The rabbits in the sham group underwent trabeculectomy and had one drop of saline instilled four times a day for 14 days. The rabbits in the mitomycin-C group underwent trabeculectomy, and a sponge soaked in 0.4mg/mL mitomycin-C was applied intraoperatively to the scleral surgical site for 3min. The rabbits in the trastuzumab group underwent trabeculectomy and were injected subconjunctivally once with 1.2mg/0.1mL of the drug. On day 14 of the experiment, the operated and control eyes were enucleated and immunohistochemically analyzed. Main Outcome Measures Mean values of fibroblast, mononuclear cell and immunostaining intensities of the transforming growth factor-[beta], fibroblast growth factor-[beta], and platelet derived growth factor. Results The mean cell numbers and immunostaining intensities in the sham group were higher than those of the control group (P<0.01). The mean cell numbers and immunostaining intensities in the mitomycin-C group and trastuzumab group were statistically significantly lower than those of the sham group (P<0.01) while mean cell numbers and immunostaining intensities in the mitomycin-C group and trastuzumab group were similar (P>0.05). Conclusion Subconjunctival trastuzumab injection effectively suppressed subconjunctival scarring after experimental glaucoma filtration surgery. BACKGROUNDTo investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery.DESIGNComparative, experimental study.SAMPLESTwenty eight eyes.METHODSTwenty-eight male New Zealand white rabbits were randomly assigned to four groups, each including seven rabbits: The rabbits in the control group were not operated on and did not receive any treatment. The rabbits in the sham group underwent trabeculectomy and had one drop of saline instilled four times a day for 14 days. The rabbits in the mitomycin-C group underwent trabeculectomy, and a sponge soaked in 0.4 mg/mL mitomycin-C was applied intraoperatively to the scleral surgical site for 3 min. The rabbits in the trastuzumab group underwent trabeculectomy and were injected subconjunctivally once with 1.2 mg/0.1 mL of the drug. On day 14 of the experiment, the operated and control eyes were enucleated and immunohistochemically analyzed.MAIN OUTCOME MEASURESMean values of fibroblast, mononuclear cell and immunostaining intensities of the transforming growth factor-β, fibroblast growth factor-β, and platelet derived growth factor.RESULTSThe mean cell numbers and immunostaining intensities in the sham group were higher than those of the control group (P < 0.01). The mean cell numbers and immunostaining intensities in the mitomycin-C group and trastuzumab group were statistically significantly lower than those of the sham group (P < 0.01) while mean cell numbers and immunostaining intensities in the mitomycin-C group and trastuzumab group were similar (P > 0.05).CONCLUSIONSubconjunctival trastuzumab injection effectively suppressed subconjunctival scarring after experimental glaucoma filtration surgery. To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery. Comparative, experimental study. Twenty eight eyes. Twenty-eight male New Zealand white rabbits were randomly assigned to four groups, each including seven rabbits: The rabbits in the control group were not operated on and did not receive any treatment. The rabbits in the sham group underwent trabeculectomy and had one drop of saline instilled four times a day for 14 days. The rabbits in the mitomycin-C group underwent trabeculectomy, and a sponge soaked in 0.4 mg/mL mitomycin-C was applied intraoperatively to the scleral surgical site for 3 min. The rabbits in the trastuzumab group underwent trabeculectomy and were injected subconjunctivally once with 1.2 mg/0.1 mL of the drug. On day 14 of the experiment, the operated and control eyes were enucleated and immunohistochemically analyzed. Mean values of fibroblast, mononuclear cell and immunostaining intensities of the transforming growth factor-β, fibroblast growth factor-β, and platelet derived growth factor. The mean cell numbers and immunostaining intensities in the sham group were higher than those of the control group (P < 0.01). The mean cell numbers and immunostaining intensities in the mitomycin-C group and trastuzumab group were statistically significantly lower than those of the sham group (P < 0.01) while mean cell numbers and immunostaining intensities in the mitomycin-C group and trastuzumab group were similar (P > 0.05). Subconjunctival trastuzumab injection effectively suppressed subconjunctival scarring after experimental glaucoma filtration surgery. Background To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery. Design Comparative, experimental study. Samples Twenty eight eyes. Methods Twenty‐eight male New Zealand white rabbits were randomly assigned to four groups, each including seven rabbits: The rabbits in the control group were not operated on and did not receive any treatment. The rabbits in the sham group underwent trabeculectomy and had one drop of saline instilled four times a day for 14 days. The rabbits in the mitomycin‐C group underwent trabeculectomy, and a sponge soaked in 0.4 mg/mL mitomycin‐C was applied intraoperatively to the scleral surgical site for 3 min. The rabbits in the trastuzumab group underwent trabeculectomy and were injected subconjunctivally once with 1.2 mg/0.1 mL of the drug. On day 14 of the experiment, the operated and control eyes were enucleated and immunohistochemically analyzed. Main Outcome Measures Mean values of fibroblast, mononuclear cell and immunostaining intensities of the transforming growth factor‐β, fibroblast growth factor‐β, and platelet derived growth factor. Results The mean cell numbers and immunostaining intensities in the sham group were higher than those of the control group (P < 0.01). The mean cell numbers and immunostaining intensities in the mitomycin‐C group and trastuzumab group were statistically significantly lower than those of the sham group (P < 0.01) while mean cell numbers and immunostaining intensities in the mitomycin‐C group and trastuzumab group were similar (P > 0.05). Conclusion Subconjunctival trastuzumab injection effectively suppressed subconjunctival scarring after experimental glaucoma filtration surgery. |
| Author | Eren, Kenan Turgut, Burak Bilir Can, Nagehan Demir, Tamer Akin, Mehmet M |
| Author_xml | – sequence: 1 givenname: Burak surname: Turgut fullname: Turgut, Burak email: drburakturgut@gmail.com organization: Department of Ophthalmology, School of Medicine, Fırat University, Elazig, Turkey – sequence: 2 givenname: Kenan surname: Eren fullname: Eren, Kenan organization: Department of Ophthalmology, School of Medicine, Fırat University, Elazig, Turkey – sequence: 3 givenname: Mehmet M surname: Akin fullname: Akin, Mehmet M organization: Department of Pathology, School of Medicine, Fırat University, Elazig, Turkey – sequence: 4 givenname: Nagehan surname: Bilir Can fullname: Bilir Can, Nagehan organization: Ophthalmology Clinics, Elazığ Education and Training Hospital, Elazig, Turkey – sequence: 5 givenname: Tamer surname: Demir fullname: Demir, Tamer organization: Department of Ophthalmology, School of Medicine, Fırat University, Elazig, Turkey |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24801440$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/sj.onc.1209685 10.1076/ceyr.27.2.35.15456 10.3109/02713683.2011.601840 10.1016/j.jcjo.2012.02.003 10.1056/NEJM198803243181205 10.1177/112067210001000203 10.1016/j.survophthal.2012.01.008 10.1001/archsurg.1995.01430090085025 10.1167/iovs.06-1121 10.1006/exer.2002.2066 10.1016/S0161-6420(96)30639-8 10.1093/annonc/mdi905 10.1016/S0161-6420(92)32025-1 10.1007/BF00946945 10.1016/S0039-6257(00)00135-1 10.1158/1078-0432.CCR-03-0549 10.1038/416279b 10.1016/S0002-9440(10)64253-8 10.1016/S0161-6420(90)32456-9 10.1097/ICU.0b013e32834ff401 10.1016/j.canlet.2005.01.041 10.1007/s004170100275 10.1001/archopht.1996.01100140151007 10.1093/annonc/mdl475 10.1038/eye.1994.44 10.1016/0002-9394(68)91288-9 10.1016/0022-3468(95)90560-X 10.1016/S1350-9462(99)00007-5 10.1038/eye.1994.43 10.2131/jts.20.1 10.1001/archopht.1988.01060130095036 10.1016/S0093-7754(01)90276-3 10.1016/j.ajo.2008.09.022 10.1097/IIO.0b013e3181924d55 10.1089/jop.1990.6.175 10.1016/0024-3205(95)02056-O 10.1167/iovs.12-9483l 10.1136/bjo.78.6.466 10.1097/00004397-200404420-00007 |
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| Copyright | 2014 Royal Australian and New Zealand College of Ophthalmologists 2014 Royal Australian and New Zealand College of Ophthalmologists. Copyright © 2015 Royal Australian and New Zealand College of Ophthalmologists |
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| References | Cordeiro MF, Gay JA, Khaw PT. Human anti-transforming growth factor-beta 2 antibody: a new glaucoma antiscarring agent. Invest Ophthalmol Vis Sci 1999; 40: 2225-2234. Cook C, Foster P. Epidemiology of glaucoma: what's new? Can J Ophthalmol 2012; 47: 223-226. Nahta R, Esteva FJ. Herceptin: mechanisms of action and resistance. Cancer Lett 2006; 232: 123-138. Cairns JE. Trabeculectomy: preliminary report of a new method. Am J Ophthalmol 1968; 66: 673-679. Baselga J, Albanell J, Molina MA, Arribas J. Mechanism of action of trastuzumab and scientific update. Semin Oncol 2001; 28: 4-11. Spiridon CI, Guinn S, Vitetta ES. A comparison of the in vitro and in vivo activities of IgG and F(ab′)2 fragments of a mixture of three monoclonal anti-Her-2 antibodies. Clin Cancer Res 2004; 10: 3542-3551. Bryant SM, Fukasawa M, Orita H, Rodgers KE, di Zerega GS. Mediation of post-surgical wound healing by macrophages. Prog Clin Biol Res 1988; 266: 273-290. Leibovich SJ, Wiseman DM. Macrophages, wound repair and angiogenesis. Prog Clin Biol Res 1988; 266: 131-145. Yamamoto T, Varani J, Soong H. Effects of 5-fluorouracil and mitomycin C on cultured rabbit subconjunctival fibroblasts. Ophthalmology 1990; 97: 1204-1210. Schultz G, Khaw PT, Oxford K, MaCauley S, Van Setten G, Chegini N. Growth factors and ocular wound healing. Eye 1994; 8: 184-187. Izumi Y, Xu L, Di Tomaso E, Fukumura D, Jain RK. Herceptin acts as an anti-angiogenic cocktail. Nature 2002; 416: 279-280. Chen CW, Huang HT, Bair JS, Lee CC. Trabeculectomy with simultaneous topical application of mitomycin-C in refractory glaucoma. J Ocul Pharmacol 1990; 6: 175-182. Wen XF, Yang G, Mao W et al. HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene 2006; 25: 6986-6996. Greenfield DS, Suner IJ, Miller MP, Kangas TA, Palmberg PF, Flynn HW. Endophthalmitis after filtering surgery with mitomycin. Arch Ophthalmol 1996; 114: 943-949. Higginbotham EJ, Stevens RK, Musch DC et al. Bleb-related endophthalmitis after trabeculectomy with mitomycin C. Ophthalmology 1996; 103: 650-656. Filippopoulos T, Hanna E, Chen TC, Grosskreutz CL, Jakobiec FA, Pasquale LR. Correlation of filtration bleb morphology with histology. Int Ophthalmol Clin 2009; 49: 71-82. Chang L, Crowston JG, Cordeiro MF, Akbar AN, Khaw PT. The role of the immune system in conjunctival wound healing after glaucoma surgery. Surv Ophthalmol 2000; 45: 49-68. Lee DA, Lee TC, Cortes AE, Kitada S. Effects of mithramycin, mitomycin C, daunorubicin, and bleomycin on human subconjunctival fibroblast attachment and proliferation. Invest Ophthalmol Vis Sci 1990; 31: 2136-2144. Pejnovic N, Lilic D, Zunic G. Aberrant levels of cytokines within the healing wound after burn injury. Arch Surg 1995; 130: 999-1006. Salim S. Current variations of glaucoma filtration surgery. Curr Opin Ophthalmol 2012; 23: 89-95. Doxey DL, Ng MC, Dill RE. Platelet-derived growth factor levels in wounds of diabetic rats. Life Sci 1995; 57: 1111-1123. Denk PO, Hoppe J, Hoppe V, Knorr M. Effect of growth factors on the activation of human Tenon's capsule fibroblasts. Curr Eye Res 2003; 27: 35-44. Baker CH, Kedar D, McCarty MF et al. Blockade of epidermal growth factor receptor signaling on tumor cells and tumor-associated endothelial cells for therapy of human carcinomas. Am J Pathol 2002; 161: 929-938. Saika S, Yamanaka O, Baba Y et al. Accumulation of latent transforming growth factor-beta binding protein-1 and TGF beta 1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts. Graefes Arch Clin Exp Ophthalmol 2001; 239: 234-241. Knorr M, Volker M, Denk PO, Wunderlich K, Thiel HJ. Proliferative response of cultured human Tenon's capsule fibroblasts to platelet-derived growth factor isoforms. Graefes Arch Clin Exp Ophthalmol 1997; 235: 667-671. Sullivan KM, Lorenz HP, Meuli M. A model of scarless human fetal wound repair is deficient in transforming growth factor beta. J Pediatr Surg 1995; 30: 198-203. Seibold LK, Sherwood MB, Kahook MY. Wound modulation after filtration surgery. Surv Ophthalmol 2012; 57: 530-559. Valabrega G, Montemurro F, Aglietta M. Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol 2007; 18: 977-984. Jampel HD, McGuigan LJB, Dunkelberger GR. Cellular proliferation after experimental glaucoma filtration surgery. Arch Ophthalmol 1988; 106: 89-94. Reder JE, Parrish RK. Update of adjunctive antimetabolities in glaucoma surgery. Ophthalmol Clin North Am 1991; 4: 861-888. Khaw PT, Occleston NL, Schutz G. Activation and suppression of fibroblast function. Eye 1994; 8: 188-195. Futamura Y, Matsumoto K. Characteristics of peripheral blood monocytes and bone marrow macrophages from rats treated with mitomycin C, 5-fluorouracil or phenylhydrazine. J Toxicol Sci 1995; 20: 1-7. Denk PO, Roth-Eichhorn S, Gressner AM, Knorr M. Effect of cytokines on regulation of the production of transforming growth factor beta-1 cultured human Tenon's capsule fibroblasts. Eur J Ophthalmol 2000; 10: 110-115. Wang XY, Crowston JG, Zoellner H, Healey PR. Interferonalpha and interferon-gamma sensitize human Tenon fibroblasts to mitomycin-C. Invest Ophthalmol Vis Sci 2007; 48: 3655-3661. Atreides SP, Skuta GL, Reynolds AC. Wound healing modulation in glaucoma filtering surgery. Int Ophthalmol Clin 2004; 44: 61-106. Broadway D, Grierson I, Hitchings R. Racial differences in the results of glaucoma filtration surgery: are racial differences in the conjunctival cell profile important? Br J Ophthalmol 1994; 78: 466-475. Occleston NL, Daniels JT, Tarnuzzer RW et al. Single exposures to antiproliferatives: long-term effects on ocular fibroblast wound-healing behavior. Invest Ophthalmol Vis Sci 1997; 38: 1998-2007. Imanishi J, Kamiyama K, Iguchi I, Kita M, Sotozono C, Kinoshita S. Growth factors: importance in wound healing and maintenance of transparency of the cornea. Prog Retin Eye Res 2000; 19: 113-129. Sener E, Yuksel N, Yildiz DK et al. The impact of subconjuctivally injected EGF and VEGF inhibitors on experimental corneal neovascularization in rat model. Curr Eye Res 2011; 36: 1005-1013. Gasparini G, Longo R, Torino F, Morabito A. Therapy of breast cancer with molecular targeting agents. Ann Oncol 2005; 16: S28-36. Pasquale LR, Thibault D, Dorman-Pease ME, Quigley HA, Jampel HD. Effect of topical mitomycin-C on glaucoma filtration surgery in monkeys. Ophthalmology 1992; 99: 14-18. Cordeiro MF, Reichel MB, Gay JA, D'Esposita F, Alexander RA, Khaw PT. Transforming growth factor-beta1, -beta2, and -beta3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring. Invest Ophthalmol Vis Sci 1999; 40: 1975-1982. Jester JV, Huang J, Petroll WM, Cavanagh HD. TGF beta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGF beta, PDGF and integrin signaling. Exp Eye Res 2002; 75: 645-657. Coleman AL. Advances in glaucoma treatment and management: surgery. Invest Ophthalmol Vis Sci 2012; 53: 2491-2494. Güler M, Yilmaz T, Ozercan I, Elkiran T. The inhibitory effects of trastuzumab on corneal neovascularization. Am J Ophthalmol 2009; 147: 703-708. Hitchings RA, Grierson I. Clinicopathologic correlation in eyes with failed fistulizing surgery. Trans Ophthalmol Soc U K 1983; 103: 84-88. Johnston RB. Current concepts: immunology. Monocytes and macrophages. N Engl J Med 1988; 318: 747-752. 1991; 4 2004; 44 2007; 18 1997; 235 1995; 30 1990; 31 1990; 97 2002; 75 2000; 45 1995; 57 1988; 266 2002; 416 1999; 40 2001; 28 2011; 36 2012; 57 1996; 103 1992; 99 1995; 130 2009; 49 2012; 53 1988; 106 1968; 66 2006; 232 1999 1995; 20 2004; 10 1994; 8 1983; 103 2002; 161 2000; 19 2000; 10 2006; 25 1994; 78 1997; 38 2003; 27 2013 2012; 47 1996; 114 2005; 16 2001; 239 2012; 23 1988; 318 2009; 147 1990; 6 2007; 48 e_1_2_5_25_1 e_1_2_5_48_1 e_1_2_5_23_1 e_1_2_5_46_1 Occleston NL (e_1_2_5_40_1) 1997; 38 e_1_2_5_44_1 Bryant SM (e_1_2_5_27_1) 1988; 266 e_1_2_5_29_1 Fellman RL (e_1_2_5_3_1) 1999 e_1_2_5_42_1 Hitchings RA (e_1_2_5_21_1) 1983; 103 e_1_2_5_15_1 e_1_2_5_38_1 e_1_2_5_17_1 e_1_2_5_36_1 e_1_2_5_11_1 e_1_2_5_7_1 Lee DA (e_1_2_5_9_1) 1990; 31 e_1_2_5_13_1 e_1_2_5_32_1 e_1_2_5_5_1 e_1_2_5_19_1 e_1_2_5_28_1 e_1_2_5_49_1 e_1_2_5_26_1 e_1_2_5_47_1 e_1_2_5_24_1 e_1_2_5_45_1 e_1_2_5_22_1 e_1_2_5_43_1 Cordeiro MF (e_1_2_5_35_1) 1999; 40 Cordeiro MF (e_1_2_5_34_1) 1999; 40 e_1_2_5_20_1 e_1_2_5_41_1 e_1_2_5_14_1 e_1_2_5_39_1 e_1_2_5_16_1 e_1_2_5_37_1 e_1_2_5_8_1 e_1_2_5_10_1 e_1_2_5_6_1 e_1_2_5_12_1 e_1_2_5_33_1 e_1_2_5_2_1 e_1_2_5_18_1 Leibovich SJ (e_1_2_5_30_1) 1988; 266 Reder JE (e_1_2_5_4_1) 1991; 4 e_1_2_5_31_1 e_1_2_5_50_1 |
| References_xml | – volume: 75 start-page: 645 year: 2002 end-page: 657 article-title: TGF beta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGF beta, PDGF and integrin signaling publication-title: Exp Eye Res – volume: 57 start-page: 530 year: 2012 end-page: 559 article-title: Wound modulation after filtration surgery publication-title: Surv Ophthalmol – volume: 57 start-page: 1111 year: 1995 end-page: 1123 article-title: Platelet‐derived growth factor levels in wounds of diabetic rats publication-title: Life Sci – volume: 130 start-page: 999 year: 1995 end-page: 1006 article-title: Aberrant levels of cytokines within the healing wound after burn injury publication-title: Arch Surg – volume: 318 start-page: 747 year: 1988 end-page: 752 article-title: Current concepts: immunology. Monocytes and macrophages publication-title: N Engl J Med – volume: 99 start-page: 14 year: 1992 end-page: 18 article-title: Effect of topical mitomycin‐C on glaucoma filtration surgery in monkeys publication-title: Ophthalmology – volume: 266 start-page: 131 year: 1988 end-page: 145 article-title: Macrophages, wound repair and angiogenesis publication-title: Prog Clin Biol Res – volume: 78 start-page: 466 year: 1994 end-page: 475 article-title: Racial differences in the results of glaucoma filtration surgery: are racial differences in the conjunctival cell profile important? publication-title: Br J Ophthalmol – volume: 49 start-page: 71 year: 2009 end-page: 82 article-title: Correlation of filtration bleb morphology with histology publication-title: Int Ophthalmol Clin – volume: 239 start-page: 234 year: 2001 end-page: 241 article-title: Accumulation of latent transforming growth factor‐beta binding protein‐1 and TGF beta 1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts publication-title: Graefes Arch Clin Exp Ophthalmol – volume: 66 start-page: 673 year: 1968 end-page: 679 article-title: Trabeculectomy: preliminary report of a new method publication-title: Am J Ophthalmol – volume: 4 start-page: 861 year: 1991 end-page: 888 article-title: Update of adjunctive antimetabolities in glaucoma surgery publication-title: Ophthalmol Clin North Am – volume: 106 start-page: 89 year: 1988 end-page: 94 article-title: Cellular proliferation after experimental glaucoma filtration surgery publication-title: Arch Ophthalmol – volume: 40 start-page: 2225 year: 1999 end-page: 2234 article-title: Human anti‐transforming growth factor‐beta 2 antibody: a new glaucoma antiscarring agent publication-title: Invest Ophthalmol Vis Sci – volume: 30 start-page: 198 year: 1995 end-page: 203 article-title: A model of scarless human fetal wound repair is deficient in transforming growth factor beta publication-title: J Pediatr Surg – volume: 103 start-page: 650 year: 1996 end-page: 656 article-title: Bleb‐related endophthalmitis after trabeculectomy with mitomycin C publication-title: Ophthalmology – volume: 45 start-page: 49 year: 2000 end-page: 68 article-title: The role of the immune system in conjunctival wound healing after glaucoma surgery publication-title: Surv Ophthalmol – volume: 147 start-page: 703 year: 2009 end-page: 708 article-title: The inhibitory effects of trastuzumab on corneal neovascularization publication-title: Am J Ophthalmol – volume: 161 start-page: 929 year: 2002 end-page: 938 article-title: Blockade of epidermal growth factor receptor signaling on tumor cells and tumor‐associated endothelial cells for therapy of human carcinomas publication-title: Am J Pathol – volume: 19 start-page: 113 year: 2000 end-page: 129 article-title: Growth factors: importance in wound healing and maintenance of transparency of the cornea publication-title: Prog Retin Eye Res – volume: 8 start-page: 188 year: 1994 end-page: 195 article-title: Activation and suppression of fibroblast function publication-title: Eye – volume: 10 start-page: 3542 year: 2004 end-page: 3551 article-title: A comparison of the in vitro and in vivo activities of IgG and F(ab′)2 fragments of a mixture of three monoclonal anti‐Her‐2 antibodies publication-title: Clin Cancer Res – start-page: 1 year: 1999 end-page: 10 – volume: 235 start-page: 667 year: 1997 end-page: 671 article-title: Proliferative response of cultured human Tenon's capsule fibroblasts to platelet‐derived growth factor isoforms publication-title: Graefes Arch Clin Exp Ophthalmol – volume: 8 start-page: 184 year: 1994 end-page: 187 article-title: Growth factors and ocular wound healing publication-title: Eye – volume: 23 start-page: 89 year: 2012 end-page: 95 article-title: Current variations of glaucoma filtration surgery publication-title: Curr Opin Ophthalmol – volume: 103 start-page: 84 year: 1983 end-page: 88 article-title: Clinicopathologic correlation in eyes with failed fistulizing surgery publication-title: Trans Ophthalmol Soc U K – volume: 10 start-page: 110 year: 2000 end-page: 115 article-title: Effect of cytokines on regulation of the production of transforming growth factor beta‐1 cultured human Tenon's capsule fibroblasts publication-title: Eur J Ophthalmol – volume: 48 start-page: 3655 year: 2007 end-page: 3661 article-title: Interferonalpha and interferon‐gamma sensitize human Tenon fibroblasts to mitomycin‐C publication-title: Invest Ophthalmol Vis Sci – volume: 16 start-page: S28 year: 2005 end-page: 36 article-title: Therapy of breast cancer with molecular targeting agents publication-title: Ann Oncol – volume: 20 start-page: 1 year: 1995 end-page: 7 article-title: Characteristics of peripheral blood monocytes and bone marrow macrophages from rats treated with mitomycin C, 5‐fluorouracil or phenylhydrazine publication-title: J Toxicol Sci – volume: 114 start-page: 943 year: 1996 end-page: 949 article-title: Endophthalmitis after filtering surgery with mitomycin publication-title: Arch Ophthalmol – volume: 18 start-page: 977 year: 2007 end-page: 984 article-title: Trastuzumab: mechanism of action, resistance and future perspectives in HER2‐overexpressing breast cancer publication-title: Ann Oncol – volume: 266 start-page: 273 year: 1988 end-page: 290 article-title: Mediation of post‐surgical wound healing by macrophages publication-title: Prog Clin Biol Res – volume: 25 start-page: 6986 year: 2006 end-page: 6996 article-title: HER2 signaling modulates the equilibrium between pro‐ and antiangiogenic factors via distinct pathways: implications for HER2‐targeted antibody therapy publication-title: Oncogene – volume: 53 start-page: 2491 year: 2012 end-page: 2494 article-title: Advances in glaucoma treatment and management: surgery publication-title: Invest Ophthalmol Vis Sci – volume: 416 start-page: 279 year: 2002 end-page: 280 article-title: Herceptin acts as an anti‐angiogenic cocktail publication-title: Nature – volume: 6 start-page: 175 year: 1990 end-page: 182 article-title: Trabeculectomy with simultaneous topical application of mitomycin‐C in refractory glaucoma publication-title: J Ocul Pharmacol – volume: 36 start-page: 1005 year: 2011 end-page: 1013 article-title: The impact of subconjuctivally injected EGF and VEGF inhibitors on experimental corneal neovascularization in rat model publication-title: Curr Eye Res – volume: 31 start-page: 2136 year: 1990 end-page: 2144 article-title: Effects of mithramycin, mitomycin C, daunorubicin, and bleomycin on human subconjunctival fibroblast attachment and proliferation publication-title: Invest Ophthalmol Vis Sci – volume: 28 start-page: 4 year: 2001 end-page: 11 article-title: Mechanism of action of trastuzumab and scientific update publication-title: Semin Oncol – volume: 232 start-page: 123 year: 2006 end-page: 138 article-title: Herceptin: mechanisms of action and resistance publication-title: Cancer Lett – volume: 47 start-page: 223 year: 2012 end-page: 226 article-title: Epidemiology of glaucoma: what's new? publication-title: Can J Ophthalmol – volume: 44 start-page: 61 year: 2004 end-page: 106 article-title: Wound healing modulation in glaucoma filtering surgery publication-title: Int Ophthalmol Clin – volume: 40 start-page: 1975 year: 1999 end-page: 1982 article-title: Transforming growth factor‐beta1, ‐beta2, and ‐beta3 in vivo: effects on normal and mitomycin C‐modulated conjunctival scarring publication-title: Invest Ophthalmol Vis Sci – volume: 38 start-page: 1998 year: 1997 end-page: 2007 article-title: Single exposures to antiproliferatives: long‐term effects on ocular fibroblast wound‐healing behavior publication-title: Invest Ophthalmol Vis Sci – volume: 97 start-page: 1204 year: 1990 end-page: 1210 article-title: Effects of 5‐fluorouracil and mitomycin C on cultured rabbit subconjunctival fibroblasts publication-title: Ophthalmology – volume: 27 start-page: 35 year: 2003 end-page: 44 article-title: Effect of growth factors on the activation of human Tenon's capsule fibroblasts publication-title: Curr Eye Res – year: 2013 – ident: e_1_2_5_18_1 doi: 10.1038/sj.onc.1209685 – ident: e_1_2_5_42_1 doi: 10.1076/ceyr.27.2.35.15456 – ident: e_1_2_5_50_1 doi: 10.3109/02713683.2011.601840 – volume: 40 start-page: 1975 year: 1999 ident: e_1_2_5_35_1 article-title: Transforming growth factor‐beta1, ‐beta2, and ‐beta3 in vivo: effects on normal and mitomycin C‐modulated conjunctival scarring publication-title: Invest Ophthalmol Vis Sci contributor: fullname: Cordeiro MF – ident: e_1_2_5_2_1 doi: 10.1016/j.jcjo.2012.02.003 – ident: e_1_2_5_28_1 doi: 10.1056/NEJM198803243181205 – ident: e_1_2_5_26_1 doi: 10.1177/112067210001000203 – volume: 40 start-page: 2225 year: 1999 ident: e_1_2_5_34_1 article-title: Human anti‐transforming growth factor‐beta 2 antibody: a new glaucoma antiscarring agent publication-title: Invest Ophthalmol Vis Sci contributor: fullname: Cordeiro MF – ident: e_1_2_5_7_1 doi: 10.1016/j.survophthal.2012.01.008 – ident: e_1_2_5_36_1 doi: 10.1001/archsurg.1995.01430090085025 – ident: e_1_2_5_43_1 doi: 10.1167/iovs.06-1121 – ident: e_1_2_5_41_1 doi: 10.1006/exer.2002.2066 – ident: e_1_2_5_13_1 doi: 10.1016/S0161-6420(96)30639-8 – volume: 103 start-page: 84 year: 1983 ident: e_1_2_5_21_1 article-title: Clinicopathologic correlation in eyes with failed fistulizing surgery publication-title: Trans Ophthalmol Soc U K contributor: fullname: Hitchings RA – ident: e_1_2_5_15_1 doi: 10.1093/annonc/mdi905 – ident: e_1_2_5_45_1 doi: 10.1016/S0161-6420(92)32025-1 – ident: e_1_2_5_24_1 doi: 10.1007/BF00946945 – ident: e_1_2_5_32_1 doi: 10.1016/S0039-6257(00)00135-1 – ident: e_1_2_5_47_1 doi: 10.1158/1078-0432.CCR-03-0549 – ident: e_1_2_5_17_1 doi: 10.1038/416279b – ident: e_1_2_5_16_1 doi: 10.1016/S0002-9440(10)64253-8 – ident: e_1_2_5_49_1 – ident: e_1_2_5_44_1 doi: 10.1016/S0161-6420(90)32456-9 – ident: e_1_2_5_6_1 doi: 10.1097/ICU.0b013e32834ff401 – volume: 266 start-page: 131 year: 1988 ident: e_1_2_5_30_1 article-title: Macrophages, wound repair and angiogenesis publication-title: Prog Clin Biol Res contributor: fullname: Leibovich SJ – ident: e_1_2_5_46_1 doi: 10.1016/j.canlet.2005.01.041 – ident: e_1_2_5_25_1 doi: 10.1007/s004170100275 – start-page: 1 volume-title: Ophthalmology year: 1999 ident: e_1_2_5_3_1 contributor: fullname: Fellman RL – ident: e_1_2_5_12_1 doi: 10.1001/archopht.1996.01100140151007 – ident: e_1_2_5_14_1 doi: 10.1093/annonc/mdl475 – ident: e_1_2_5_23_1 doi: 10.1038/eye.1994.44 – ident: e_1_2_5_20_1 doi: 10.1016/0002-9394(68)91288-9 – volume: 266 start-page: 273 year: 1988 ident: e_1_2_5_27_1 article-title: Mediation of post‐surgical wound healing by macrophages publication-title: Prog Clin Biol Res contributor: fullname: Bryant SM – ident: e_1_2_5_37_1 doi: 10.1016/0022-3468(95)90560-X – ident: e_1_2_5_33_1 doi: 10.1016/S1350-9462(99)00007-5 – ident: e_1_2_5_39_1 doi: 10.1038/eye.1994.43 – ident: e_1_2_5_31_1 doi: 10.2131/jts.20.1 – ident: e_1_2_5_11_1 doi: 10.1001/archopht.1988.01060130095036 – volume: 4 start-page: 861 year: 1991 ident: e_1_2_5_4_1 article-title: Update of adjunctive antimetabolities in glaucoma surgery publication-title: Ophthalmol Clin North Am contributor: fullname: Reder JE – ident: e_1_2_5_48_1 doi: 10.1016/S0093-7754(01)90276-3 – ident: e_1_2_5_19_1 doi: 10.1016/j.ajo.2008.09.022 – ident: e_1_2_5_22_1 doi: 10.1097/IIO.0b013e3181924d55 – volume: 38 start-page: 1998 year: 1997 ident: e_1_2_5_40_1 article-title: Single exposures to antiproliferatives: long‐term effects on ocular fibroblast wound‐healing behavior publication-title: Invest Ophthalmol Vis Sci contributor: fullname: Occleston NL – ident: e_1_2_5_10_1 doi: 10.1089/jop.1990.6.175 – ident: e_1_2_5_38_1 doi: 10.1016/0024-3205(95)02056-O – ident: e_1_2_5_5_1 doi: 10.1167/iovs.12-9483l – ident: e_1_2_5_29_1 doi: 10.1136/bjo.78.6.466 – volume: 31 start-page: 2136 year: 1990 ident: e_1_2_5_9_1 article-title: Effects of mithramycin, mitomycin C, daunorubicin, and bleomycin on human subconjunctival fibroblast attachment and proliferation publication-title: Invest Ophthalmol Vis Sci contributor: fullname: Lee DA – ident: e_1_2_5_8_1 doi: 10.1097/00004397-200404420-00007 |
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| Snippet | Background
To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery.
Design... To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery. Comparative,... Abstract Background To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery.... Background To investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration surgery. Design... BACKGROUNDTo investigate the effects of subconjunctivally administered trastuzumab on wound healing in experimental glaucoma filtration... |
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| SubjectTerms | Alkylating Agents - administration & dosage animal model Animals Antibodies, Monoclonal, Humanized - pharmacology Antineoplastic Agents - pharmacology Conjunctiva - drug effects Conjunctiva - metabolism Disease Models, Animal Fibroblast Growth Factors - metabolism glaucoma Glaucoma - surgery Immunoenzyme Techniques Injections, Intraocular Male mitomycin Mitomycin - administration & dosage Older people Platelet-Derived Growth Factor - metabolism Rabbits Sclera - drug effects Sclera - metabolism Surgery Tenon Capsule - drug effects Tenon Capsule - metabolism Trabeculectomy Transforming Growth Factor beta - metabolism Trastuzumab Wound healing Wound Healing - drug effects |
| Title | Impact of trastuzumab on wound healing in experimental glaucoma surgery |
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