Effects of Amburoside A and Isokaempferide, Polyphenols from Amburana cearensis, on Rodent Inflammatory Processes and Myeloperoxidase Activity in Human Neutrophils
: The present study evaluated the anti‐inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk bark of Amburana cearensis, a medicinal plant used in northeast Brazil for the treatment of asthma. Animals (male Wistar rats or Swiss mice) pre...
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Published in | Basic & clinical pharmacology & toxicology Vol. 104; no. 3; pp. 198 - 205 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Malden, USA
Blackwell Publishing Inc
01.03.2009
Blackwell |
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Abstract | : The present study evaluated the anti‐inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk bark of Amburana cearensis, a medicinal plant used in northeast Brazil for the treatment of asthma. Animals (male Wistar rats or Swiss mice) pre‐treated with amburoside A (25 and 50 mg/kg) or isokaempferide (12.5, 25 and 50 mg/kg), orally or intraperitoneally, showed a significant inhibition of the paw oedema induced by carrageenan (1%), prostaglandin E2 (30 nmol/paw), histamine (200 µg/paw) or serotonin (200 µg/paw). Histological and morphometric evaluations of the rat paw oedema induced by carrageenan showed that amburoside A and isokaempferide also inhibited the accumulation of inflammatory cells. Amburoside A reduced significantly the paw oedema and the increase in vascular permeability induced by dextran, as related to the control group. Similar results were observed with the isokaempferide pre‐treatment. Furthermore, amburoside A or isokaempferide inhibited both leucocyte and neutrophil migrations, in mouse peritoneal cavity, after the carrageenan injection. The polyphenols were not cytotoxic and blocked N‐formyl‐methyl‐leucyl‐phenylalanine‐induced myeloperoxidase release and activity in human neutrophils. In addition, amburoside A and isokaempferide at 50 and 100 µg/ml concentrations reduced significantly the lipopolysaccharide‐mediated increase in tumour necrosis factor‐α (TNF‐α) levels. These results provide, for the first time, evidence to support the anti‐inflammatory activity of amburoside A and isokaempferide that seems to be related to an inhibition of inflammatory mediators, such as TNF‐α, as well as histamine, serotonin and prostaglandin E2, besides leucocyte infiltration in a dose‐ or concentration‐dependent manner. These anti‐inflammatory effects can be explained, at least in part, by the ability of these compounds to reduce neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF‐α secretion. |
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AbstractList | The present study evaluated the anti-inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk bark of Amburana cearensis, a medicinal plant used in northeast Brazil for the treatment of asthma. Animals (male Wistar rats or Swiss mice) pre-treated with amburoside A (25 and 50 mg/kg) or isokaempferide (12.5, 25 and 50 mg/kg), orally or intraperitoneally, showed a significant inhibition of the paw oedema induced by carrageenan (1%), prostaglandin E2 (30 nmol/paw), histamine (200 mu g/paw) or serotonin (200 mu g/paw). Histological and morphometric evaluations of the rat paw oedema induced by carrageenan showed that amburoside A and isokaempferide also inhibited the accumulation of inflammatory cells. Amburoside A reduced significantly the paw oedema and the increase in vascular permeability induced by dextran, as related to the control group. Similar results were observed with the isokaempferide pre-treatment. Furthermore, amburoside A or isokaempferide inhibited both leucocyte and neutrophil migrations, in mouse peritoneal cavity, after the carrageenan injection. The polyphenols were not cytotoxic and blocked N-formyl-methyl-leucyl-phenylalanine-induced myeloperoxidase release and activity in human neutrophils. In addition, amburoside A and isokaempferide at 50 and 100 mu g/ml concentrations reduced significantly the lipopolysaccharide-mediated increase in tumour necrosis factor- alpha (TNF- alpha ) levels. These results provide, for the first time, evidence to support the anti-inflammatory activity of amburoside A and isokaempferide that seems to be related to an inhibition of inflammatory mediators, such as TNF- alpha , as well as histamine, serotonin and prostaglandin E2, besides leucocyte infiltration in a dose- or concentration-dependent manner. These anti-inflammatory effects can be explained, at least in part, by the ability of these compounds to reduce neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF- alpha secretion. : The present study evaluated the anti‐inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk bark of Amburana cearensis, a medicinal plant used in northeast Brazil for the treatment of asthma. Animals (male Wistar rats or Swiss mice) pre‐treated with amburoside A (25 and 50 mg/kg) or isokaempferide (12.5, 25 and 50 mg/kg), orally or intraperitoneally, showed a significant inhibition of the paw oedema induced by carrageenan (1%), prostaglandin E2 (30 nmol/paw), histamine (200 µg/paw) or serotonin (200 µg/paw). Histological and morphometric evaluations of the rat paw oedema induced by carrageenan showed that amburoside A and isokaempferide also inhibited the accumulation of inflammatory cells. Amburoside A reduced significantly the paw oedema and the increase in vascular permeability induced by dextran, as related to the control group. Similar results were observed with the isokaempferide pre‐treatment. Furthermore, amburoside A or isokaempferide inhibited both leucocyte and neutrophil migrations, in mouse peritoneal cavity, after the carrageenan injection. The polyphenols were not cytotoxic and blocked N‐formyl‐methyl‐leucyl‐phenylalanine‐induced myeloperoxidase release and activity in human neutrophils. In addition, amburoside A and isokaempferide at 50 and 100 µg/ml concentrations reduced significantly the lipopolysaccharide‐mediated increase in tumour necrosis factor‐α (TNF‐α) levels. These results provide, for the first time, evidence to support the anti‐inflammatory activity of amburoside A and isokaempferide that seems to be related to an inhibition of inflammatory mediators, such as TNF‐α, as well as histamine, serotonin and prostaglandin E2, besides leucocyte infiltration in a dose‐ or concentration‐dependent manner. These anti‐inflammatory effects can be explained, at least in part, by the ability of these compounds to reduce neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF‐α secretion. The present study evaluated the anti‐inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk bark of Amburana cearensis , a medicinal plant used in northeast Brazil for the treatment of asthma. Animals (male Wistar rats or Swiss mice) pre‐treated with amburoside A (25 and 50 mg/kg) or isokaempferide (12.5, 25 and 50 mg/kg), orally or intraperitoneally, showed a significant inhibition of the paw oedema induced by carrageenan (1%), prostaglandin E 2 (30 nmol/paw), histamine (200 µg/paw) or serotonin (200 µg/paw). Histological and morphometric evaluations of the rat paw oedema induced by carrageenan showed that amburoside A and isokaempferide also inhibited the accumulation of inflammatory cells. Amburoside A reduced significantly the paw oedema and the increase in vascular permeability induced by dextran, as related to the control group. Similar results were observed with the isokaempferide pre‐treatment. Furthermore, amburoside A or isokaempferide inhibited both leucocyte and neutrophil migrations, in mouse peritoneal cavity, after the carrageenan injection. The polyphenols were not cytotoxic and blocked N‐formyl‐methyl‐leucyl‐phenylalanine‐induced myeloperoxidase release and activity in human neutrophils. In addition, amburoside A and isokaempferide at 50 and 100 µg/ml concentrations reduced significantly the lipopolysaccharide‐mediated increase in tumour necrosis factor‐α (TNF‐α) levels. These results provide, for the first time, evidence to support the anti‐inflammatory activity of amburoside A and isokaempferide that seems to be related to an inhibition of inflammatory mediators, such as TNF‐α, as well as histamine, serotonin and prostaglandin E 2 , besides leucocyte infiltration in a dose‐ or concentration‐dependent manner. These anti‐inflammatory effects can be explained, at least in part, by the ability of these compounds to reduce neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF‐α secretion. The present study evaluated the anti-inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk bark of Amburana cearensis, a medicinal plant used in northeast Brazil for the treatment of asthma. Animals (male Wistar rats or Swiss mice) pre-treated with amburoside A (25 and 50 mg/kg) or isokaempferide (12.5, 25 and 50 mg/kg), orally or intraperitoneally, showed a significant inhibition of the paw oedema induced by carrageenan (1%), prostaglandin E(2) (30 nmol/paw), histamine (200 microg/paw) or serotonin (200 microg/paw). Histological and morphometric evaluations of the rat paw oedema induced by carrageenan showed that amburoside A and isokaempferide also inhibited the accumulation of inflammatory cells. Amburoside A reduced significantly the paw oedema and the increase in vascular permeability induced by dextran, as related to the control group. Similar results were observed with the isokaempferide pre-treatment. Furthermore, amburoside A or isokaempferide inhibited both leucocyte and neutrophil migrations, in mouse peritoneal cavity, after the carrageenan injection. The polyphenols were not cytotoxic and blocked N-formyl-methyl-leucyl-phenylalanine-induced myeloperoxidase release and activity in human neutrophils. In addition, amburoside A and isokaempferide at 50 and 100 microg/ml concentrations reduced significantly the lipopolysaccharide-mediated increase in tumour necrosis factor-alpha (TNF-alpha) levels. These results provide, for the first time, evidence to support the anti-inflammatory activity of amburoside A and isokaempferide that seems to be related to an inhibition of inflammatory mediators, such as TNF-alpha, as well as histamine, serotonin and prostaglandin E(2), besides leucocyte infiltration in a dose- or concentration-dependent manner. These anti-inflammatory effects can be explained, at least in part, by the ability of these compounds to reduce neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. |
Author | Vasconcelos, Silvânia Mendes Nobre‐Júnior, Hélio Vitoriano Canuto, Kirley Marques Andrade, Geane Matos De Barros Viana, Glauce Socorro Da Silva Costa, Kassiane Cristine Fontenele, Juvênia Bezerra Ferreira, Márcia Valéria Pitombeira Leal, Luzia Kalyne Almeida Moreira Silveira, Edilberto Rocha |
Author_xml | – sequence: 1 givenname: Luzia Kalyne Almeida Moreira surname: Leal fullname: Leal, Luzia Kalyne Almeida Moreira – sequence: 2 givenname: Kirley Marques surname: Canuto fullname: Canuto, Kirley Marques – sequence: 3 givenname: Kassiane Cristine surname: Da Silva Costa fullname: Da Silva Costa, Kassiane Cristine – sequence: 4 givenname: Hélio Vitoriano surname: Nobre‐Júnior fullname: Nobre‐Júnior, Hélio Vitoriano – sequence: 5 givenname: Silvânia Mendes surname: Vasconcelos fullname: Vasconcelos, Silvânia Mendes – sequence: 6 givenname: Edilberto Rocha surname: Silveira fullname: Silveira, Edilberto Rocha – sequence: 7 givenname: Márcia Valéria Pitombeira surname: Ferreira fullname: Ferreira, Márcia Valéria Pitombeira – sequence: 8 givenname: Juvênia Bezerra surname: Fontenele fullname: Fontenele, Juvênia Bezerra – sequence: 9 givenname: Geane Matos surname: Andrade fullname: Andrade, Geane Matos – sequence: 10 givenname: Glauce Socorro surname: De Barros Viana fullname: De Barros Viana, Glauce Socorro |
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Snippet | : The present study evaluated the anti‐inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk... The present study evaluated the anti-inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk bark of... The present study evaluated the anti‐inflammatory activity of amburoside A (a phenol glucoside) and isokaempferide (a flavonol) isolated from the trunk bark of... |
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SubjectTerms | Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Biological and medical sciences Brazil Disease Models, Animal Dose-Response Relationship, Drug Fabaceae - chemistry Flavonoids - administration & dosage Flavonoids - isolation & purification Flavonoids - pharmacology Flavonoids - toxicity Glucosides - administration & dosage Glucosides - isolation & purification Glucosides - pharmacology Humans Inflammation - drug therapy Inflammation - physiopathology Inflammation Mediators - metabolism Male Medical sciences Medicine, Traditional Mice Neutrophils - drug effects Neutrophils - metabolism Peroxidase - drug effects Peroxidase - metabolism Pharmacology. Drug treatments Phenols - isolation & purification Phenols - pharmacology Phenols - toxicity Plant Bark Plant Extracts - administration & dosage Plant Extracts - pharmacology Polyphenols Rats Rats, Wistar Tumor Necrosis Factor-alpha - drug effects Tumor Necrosis Factor-alpha - secretion |
Title | Effects of Amburoside A and Isokaempferide, Polyphenols from Amburana cearensis, on Rodent Inflammatory Processes and Myeloperoxidase Activity in Human Neutrophils |
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