Pancreatic β-cell mass in European subjects with type 2 diabetes

• Published in: Diabetes, obesity & metabolism Vol. 10; no. s4; pp. 32 - 42
• Main Authors: Rahier, J, Guiot, Y, Goebbels, R.M, Sempoux, C, Henquin, J.C
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.11.2008; Blackwell Publishing Ltd
• Subjects: Adult; Aged; Aged, 80 and over; Autopsy - methods; Blood Glucose - metabolism; Body Mass Index; Diabetes Mellitus, Type 2 - pathology; Disease Progression; European Continental Ancestry Group; Female; Humans; insulin content; Insulin Resistance - physiology; insulin secretion; Insulin-Secreting Cells - metabolism; Insulin-Secreting Cells - pathology; Male; Middle Aged; morphometry; noninsulin-dependent diabetes mellitus; Obesity - complications; Pancreas - pathology; pancreatic islet; pathophysiology; type 2 diabetes; β-cell dysfunction; β-cell mass

Decreases in both β-cell function and number can contribute to insulin deficiency in type 2 diabetes. Here, we quantified the β-cell mass in pancreas obtained at autopsy of 57 type 2 diabetic (T2D) and 52 non-diabetic subjects of European origin. Sections from the body and tail were immunostained fo...