DNA Mismatch Repair Protein (MSH6) Correlated With the Responses of Atypical Pituitary Adenomas and Pituitary Carcinomas to Temozolomide: The National Cooperative Study by the Japan Society for Hypothalamic and Pituitary Tumors

• Published in: The journal of clinical endocrinology and metabolism Vol. 98; no. 3; pp. 1130 - 1136
• Main Authors: Hirohata, Toshio, Asano, Kenichiro, Ogawa, Yoshikazu, Takano, Shingo, Amano, Kosaku, Isozaki, Osamu, Iwai, Yoshiyasu, Sakata, Kiyohiko, Fukuhara, Noriaki, Nishioka, Hiroshi, Yamada, Shozo, Fujio, Shingo, Arita, Kazunori, Takano, Koji, Tominaga, Atsushi, Hizuka, Naomi, Ikeda, Hidetoshi, Osamura, R. Yoshiyuki, Tahara, Shigeyuki, Ishii, Yudo, Kawamata, Takakazu, Shimatsu, Akira, Teramoto, Akira, Matsuno, Akira
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Oxford University Press 01.03.2013; Copyright by The Endocrine Society; Endocrine Society
• Subjects: Adenoma; Adenoma - drug therapy; Adenoma - metabolism; Adenoma - pathology; Adrenocorticotropic hormone; Adult; Aged; Antineoplastic Agents, Alkylating - therapeutic use; Biological and medical sciences; Brain tumors; Carcinoma; Dacarbazine - analogs & derivatives; Dacarbazine - therapeutic use; Data Collection; DNA methyltransferase; DNA Modification Methylases - metabolism; DNA repair; DNA Repair Enzymes - metabolism; DNA-Binding Proteins - metabolism; Drug Resistance, Neoplasm - physiology; Endocrinopathies; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Humans; Hypothalamus; Hypothalamus. Hypophysis. Epiphysis (diseases); Immunohistochemistry; Japan; Ki-67 Antigen - metabolism; Male; Medical sciences; Middle Aged; Mismatch repair; MSH6 protein; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Null cells; p53 Protein; Pituitary (anterior); Pituitary hormones; Pituitary Neoplasms - drug therapy; Pituitary Neoplasms - metabolism; Pituitary Neoplasms - pathology; Prolactin; Retrospective Studies; Solid tumors; Temozolomide; Tumor Suppressor Protein p53 - metabolism; Tumor Suppressor Proteins - metabolism; Tumors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Young Adult; Asia; Japan; Endocrinopathy; Antineoplastic agent; Obesity; Endocrine gland; Carcinoma; Nutrition; Nutrition disorder; Metabolic diseases; Malignant tumor; Protein; Alkylating agent; DNA; Pituitary diseases; Pituitary adenoma; Pituitary gland; Atypical; Society; Temozolomide; Repair; Endocrinology; Nutritional status; Cancer

Context:Temozolomide (TMZ) is an alkylating agent and was a first-line chemotherapeutic agent for malignant gliomas. Recently, TMZ has been documented to be effective against atypical pituitary adenomas (APAs) and pituitary carcinomas (PCs).Objective:The clinical and pathological characteristics of...