Val1483Ile in FASN Gene Is Linked to Central Obesity and Insulin Sensitivity in Adult White Men

• Published in: Obesity (Silver Spring, Md.) Vol. 17; no. 9; pp. 1755 - 1761
• Main Authors: Moreno‐Navarrete, José M., Botas, Patricia, Valdés, Sergio, Ortega, Francisco J., Delgado, Elías, Vázquez‐Martín, Alejandro, Bassols, Judit, Pardo, Gerard, Ricart, Wifredo, Menéndez, Javier A., Fernández‐Real, José M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.09.2009
• Subjects: Adipose Tissue - enzymology; Adipose Tissue - physiopathology; Adiposity - genetics; Adult; Age Factors; Blood Glucose - genetics; Blood pressure; Blood Pressure - genetics; Body fat; Body Mass Index; Case-Control Studies; Diabetes; Down-Regulation; Enzymes; Fatty Acid Synthase, Type I - genetics; Fatty Acid Synthase, Type I - metabolism; Fatty acids; Female; Gene expression; Gene Frequency; Genetic Predisposition to Disease; Glucose; Homeostasis; Humans; Insulin resistance; Insulin Resistance - genetics; Isoleucine; Male; Metabolism; Middle Aged; Obesity; Obesity - enzymology; Obesity - genetics; Obesity - physiopathology; Obesity - prevention & control; Phenotype; Polymorphism; Polymorphism, Single Nucleotide; Risk Factors; Sex Factors; Systemic diseases; Time Factors; Valine; Waist-Hip Ratio; Weight Gain - genetics; White people; Spain

The Val1483Ile polymorphism in the human fatty acid synthase (FASN) gene is located within the interdomain region of the FASN close to the two dynamic active centers of the FASN enzyme and putatively affects FASN action. We aimed to evaluate the association of this polymorphism with obesity phenotyp...