Functional characterization of mannose receptor expressed by immunocompetent mouse microglia

• Published in: Glia Vol. 42; no. 1; pp. 89 - 100
• Main Authors: Zimmer, Heiko, Riese, Sigrid, Régnier-Vigouroux, Anne
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.04.2003; Wiley-Liss
• Subjects: Animals; Biological and medical sciences; Cells, Cultured; CNS immunity; cytokines; Fundamental and applied biological sciences. Psychology; Immunocompetence - physiology; Interferon-gamma - pharmacology; Interleukin-4 - pharmacology; Isolated neuron and nerve. Neuroglia; Lectins, C-Type; mannose receptor; Mannose-Binding Lectins; Mice; Mice, Inbred BALB C; microglia; Microglia - immunology; Microglia - metabolism; pinocytosis; Receptors, Cell Surface - biosynthesis; Receptors, Cell Surface - physiology; Vertebrates: nervous system and sense organs; pinocytosis; Neuroglia; Rodentia; Cytokine; Mannose; Gene expression; Microglia; Characterization; Vertebrata; Mammalia; Mouse; CNS immunity; cytokines; mannose receptor; Biological receptor

The mannose receptor is a pattern‐recognition receptor involved in innate and adaptive immunity. The receptor is mainly expressed by macrophages and, within the brain, by astrocytes and microglia. This study reports for the first time the effects of two classical proinflammatory (interferon‐γ, IFNγ)...