Red blood cell alloimmunization in sickle cell disease and in thalassaemia: current status, future perspectives and potential role of molecular typing

• Published in: Vox sanguinis Vol. 106; no. 3; pp. 197 - 208
• Main Authors: Matteocci, A., Pierelli, L.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.04.2014; S. Karger AG
• Subjects: Anemia, Sickle Cell - blood; Anemia, Sickle Cell - immunology; Anemia, Sickle Cell - therapy; Antigens; Blood Group Incompatibility - blood; Blood Group Incompatibility - complications; Blood Group Incompatibility - immunology; Blood Grouping and Crossmatching - methods; Blood Grouping and Crossmatching - standards; Blood Grouping and Crossmatching - trends; blood groups; Blood Transfusion - standards; Blood Transfusion - trends; Blood transfusions; Erythrocytes; Forecasting; genotyping; Humans; Immunization, Passive - trends; immunohaematology; Isoantibodies - biosynthesis; Isoantibodies - blood; Molecular biology; RBC antigens and antibodies; Risk Factors; Sickle cell disease; Thalassemia - blood; Thalassemia - immunology; Thalassemia - therapy; Transfusion Reaction; transfusion strategy; transfusion strategy; blood groups; RBC antigens and antibodies; immunohaematology; genotyping

Red blood cell (RBC) transfusions are a milestone in the treatment for sickle cell anaemia (SSA) and for thalassaemia. RBC alloimmunization remains a major challenge of chronic transfusion therapy, and it can lead to adverse life‐threatening events. The alloimmunization risk could depend on multiple...