T regulatory cell phenotypes in peripheral blood and bronchoalveolar lavage from non-asthmatic and asthmatic subjects

• Published in: Clinical and experimental allergy Vol. 45; no. 11; pp. 1654 - 1662
• Main Authors: Baatjes, A. J., Smith, S. G., Watson, R., Howie, K., Murphy, D., Larché, M., Denburg, J. A., Inman, M. D., O'Byrne, P. M.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.11.2015; Wiley Subscription Services, Inc
• Subjects: Adult; Antigens, Surface - metabolism; asthma; Asthma - immunology; Asthma - metabolism; Asthma - physiopathology; BAL; Bronchoalveolar Lavage Fluid - cytology; Bronchoalveolar Lavage Fluid - immunology; Case-Control Studies; CD4 Lymphocyte Count; Female; flow cytometry; Forkhead Transcription Factors - metabolism; Foxp3; Humans; Immunophenotyping; Middle Aged; peripheral blood; Phenotype; suppression assay; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; T regulatory cell; Young Adult; T regulatory cell; asthma; flow cytometry; peripheral blood; Foxp3; BAL; suppression assay

Summary Background An unresolved issue in T regulatory cells' cell biology is the lack of consensus on phenotypic markers that accurately define the natural Treg (nTreg) population. Objectives To examine nTreg frequency and functional capacity in healthy controls and their frequency in asthmati...