Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus - Smith, Siobhán; Gabhann, Joan Nı´; Higgs, Rowan; Stacey, Kevin; Wahren-Herlenius, Marie; Espinosa, Alexander; Totaro, Maria Grazia; Sica, Antonio; Ball, Elizabeth; Bell, Aubrey; Johnston, James; Browne, Peter; et al. (Arthritis & rheumatology (Hoboken, N.J.), 2012)
Keywords: Animals; Biological and medical sciences; Bone Marrow Cells - drug effects; Bone Marrow Cells - metabolism; Chromatin Immunoprecipitation; Disease Models, Animal; Diseases of the osteoarticular system; Female; Gene Expression Regulation; Genes; Humans; Interferon Regulatory Factor-3 - genetics; Interferon Regulatory Factor-3 - metabolism; Interleukin-23 Subunit p19 - genetics; Interleukin-23 Subunit p19 - metabolism; Kinases; Lupus; Lupus Erythematosus, Systemic - metabolism; Macrophages - drug effects; Macrophages - metabolism; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes - metabolism; Poly I-C - pharmacology; Protein Array Analysis - methods; Protein Binding; Protein-Serine-Threonine Kinases - pharmacology; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Toll-Like Receptor 3 - immunology; Promoter; Immunopathology; Connective tissue disease; Skin disease; Systemic lupus erythematosus; Systemic disease; Rheumatology; Autoimmune disease; Interferon