Antibody 27F3 Broadly Targets Influenza A Group 1 and 2 Hemagglutinins through a Further Variation in VH1-69 Antibody Orientation on the HA Stem

• Published in: Cell reports (Cambridge) Vol. 20; no. 12; pp. 2935 - 2943
• Main Authors: Lang, Shanshan, Xie, Jia, Zhu, Xueyong, Wu, Nicholas C., Lerner, Richard A., Wilson, Ian A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.09.2017; Elsevier
• Subjects: antibody family; broadly neutralizing antibodies; crystal structure; hemagglutinin; influenza virus; phage display; VH1-69; phage display; hemagglutinin; influenza virus; crystal structure; antibody family; broadly neutralizing antibodies; VH1-69

Antibodies that target both group 1 and group 2 influenza A viruses are valuable for therapeutic and vaccine development, but only a few have been reported to date. Here, we describe a new VH1-69 antibody 27F3 that broadly recognizes heterosubtypic hemagglutinins (HAs) from both group 1 and group 2...