Gene Expression Profiling Reveals Renin mRNA Overexpression in Human Hypertensive Kidneys and a Role for MicroRNAs

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 58; no. 6; pp. 1093 - 1098
• Main Authors: Marques, Francine Z., Campain, Anna E., Tomaszewski, Maciej, Zukowska-Szczechowska, Ewa, Yang, Yee Hwa J., Charchar, Fadi J., Morris, Brian J.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.12.2011; Lippincott Williams & Wilkins
• Subjects: 3' Untranslated Regions; Adult; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Experimental diseases; Gene Expression Profiling; Genes, Reporter; Humans; Hypertension - genetics; Hypertension - metabolism; Kidney Cortex - metabolism; Kidney Medulla - metabolism; Male; Medical sciences; MicroRNAs - genetics; MicroRNAs - physiology; Renin - biosynthesis; Renin - genetics; RNA, Messenger - biosynthesis; Human; Hypertension; microRNAs; Enzyme; Cardiovascular disease; Gene expression; microarrays; Peptidases; kidney; Renin angiotensin system; Renin; Hydrolases; Aspartic endopeptidases

The kidney has long been invoked in the etiology of essential hypertension. This could involve alterations in expression of specific genes and microRNAs (miRNAs). The aim of the present study was to identify, at the transcriptome-wide level, mRNAs and miRNAs that were differentially expressed betwee...