Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder

• Published in: Developmental neurobiology (Hoboken, N.J.) Vol. 78; no. 5; pp. 474 - 499
• Main Authors: Needham, Brittany D., Tang, Weiyi, Wu, Wei‐Li
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2018
• Subjects: Animal models; Animals; Antibiotics; Autism; Autism spectrum disorder (ASD); Autism Spectrum Disorder - microbiology; Autism Spectrum Disorder - psychology; Digestive system; Disease Models, Animal; Gastrointestinal Microbiome; Gastrointestinal tract; germ‐free (GF); gut microbiota; gut–brain axis; High fat diet; Immune response; Intestinal microflora; Intestine; Mental disorders; Microbiota; Neural networks; Probiotics; Researchers; Rodentia; Social Behavior; Therapeutic applications; Valproic acid; germ-free (GF); Autism spectrum disorder (ASD); social behavior; gut microbiota; gut-brain axis

ABSTRACT Social impairment is one of the major symptoms in multiple psychiatric disorders, including autism spectrum disorder (ASD). Accumulated studies indicate a crucial role for the gut microbiota in social development, but these mechanisms remain unclear. This review focuses on two strategies ad...