Extracellular vesicles carry transcriptional ‘dark matter’ revealing tissue‐specific information

• Published in: Journal of extracellular vesicles Vol. 13; no. 8; pp. e12481 - n/a
• Main Authors: Dogra, Navneet, Chen, Tzu‐Yi, Gonzalez‐Kozlova, Edgar, Miceli, Rebecca, Cordon‐Cardo, Carlos, Tewari, Ashutosh K., Losic, Bojan, Stolovitzky, Gustavo
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.08.2024; Wiley
• Subjects: Annotations; biofluids; Biopsy; Cancer; Cell Line, Tumor; Clinical trials; Dark matter; Datasets; Electron microscopes; Epithelial cells; Extracellular vesicles; Extracellular Vesicles - metabolism; Gene expression; Gene Expression Regulation, Neoplastic; Genomes; Genomics; Homeostasis; Humans; liquid biopsy; Male; Organ Specificity - genetics; Phenotypes; Prokaryotes; Prostate cancer; Prostate carcinoma; Prostatectomy; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; RNA sequencing; small RNA; Transcriptome; Transcriptomes; Transcriptomics; Transmission electron microscopy; RNA sequencing; biofluids; cancer; extracellular vesicles; small RNA; liquid biopsy

From eukaryotes to prokaryotes, all cells secrete extracellular vesicles (EVs) as part of their regular homeostasis, intercellular communication, and cargo disposal. Accumulating evidence suggests that small EVs carry functional small RNAs, potentially serving as extracellular messengers and liquid‐...