Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model - Saadeddin, Anas; Purohit, Vivek; Huh, Yeamin; Wong, Mei; Maulny, Aurelia; Dowty, Martin E.; Sagawa, Kazuko (The AAPS journal, 2024)
Keywords: Alopecia Areata; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biotechnology; Humans; Pharmacology/Toxicology; Pharmacy; Probability; Protein Kinase Inhibitors; Research Article; Risk Assessment; Therapeutic Equivalency; ritlecitinib; virtual bioequivalence; clinical variability; intra-subject coefficient of variation; physiologically based pharmacokinetic