Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis
(1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with...
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| Published in | Cells (Basel, Switzerland) Vol. 10; no. 8; p. 2150 |
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| Format | Journal Article |
| Language | English |
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| Abstract | (1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D. (2) We performed a systematic review and meta-analysis of SGLT2-i therapy on T2D patients, reporting data on changes in EAT after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random effects or fixed effects model meta-analysis was then applied. (3) Results: A total of three studies (n = 64 patients with SGLT2-i, n = 62 with standard therapy) were included in the final analysis. SGLT2 inhibitors reduced EAT (SMD: −0.82 (−1.49; −0.15); p < 0.0001). An exploratory analysis showed that HbA1c was significantly reduced with SGLT2-i use, while body mass index was not significantly reduced with this drug. (4) Conclusions: This meta-analysis suggests that the amount of EAT is significantly reduced in T2D patients with SGLT2-i treatment. |
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| AbstractList | (1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D. (2) We performed a systematic review and meta-analysis of SGLT2-i therapy on T2D patients, reporting data on changes in EAT after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random effects or fixed effects model meta-analysis was then applied. (3) Results: A total of three studies (
n
= 64 patients with SGLT2-i,
n
= 62 with standard therapy) were included in the final analysis. SGLT2 inhibitors reduced EAT (SMD: −0.82 (−1.49; −0.15);
p
< 0.0001). An exploratory analysis showed that HbA1c was significantly reduced with SGLT2-i use, while body mass index was not significantly reduced with this drug. (4) Conclusions: This meta-analysis suggests that the amount of EAT is significantly reduced in T2D patients with SGLT2-i treatment. (1) Sodium–glucose cotransporter-2 inhibitors (SGLT2-i) reduce adipose tissue and cardiovascular events in patients with type 2 diabetes (T2D). Accumulation of epicardial adipose tissue (EAT) is associated with increased cardio-metabolic risks and obstructive coronary disease events in patients with T2D. (2) We performed a systematic review and meta-analysis of SGLT2-i therapy on T2D patients, reporting data on changes in EAT after searching the PubMed/MEDLINE, Embase, Science Direct, Scopus, Google Scholar, and Cochrane databases. A random effects or fixed effects model meta-analysis was then applied. (3) Results: A total of three studies (n = 64 patients with SGLT2-i, n = 62 with standard therapy) were included in the final analysis. SGLT2 inhibitors reduced EAT (SMD: −0.82 (−1.49; −0.15); p < 0.0001). An exploratory analysis showed that HbA1c was significantly reduced with SGLT2-i use, while body mass index was not significantly reduced with this drug. (4) Conclusions: This meta-analysis suggests that the amount of EAT is significantly reduced in T2D patients with SGLT2-i treatment. |
| Author | Masson, Walter Nogueira, Juan Patricio Lavalle-Cobo, Augusto |
| AuthorAffiliation | 2 Endocrinology, Nutrition and Metabolism Investigation Center, Faculty of Health Science, National University of Formosa, Formosa 3600, Argentina 1 Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Buenos Aires 1115, Argentina; walter.masson@hospitalitaliano.org.ar (W.M.); augustolavalle@gmail.com (A.L.-C.) |
| AuthorAffiliation_xml | – name: 1 Council of Epidemiology and Cardiovascular Prevention, Argentine Society of Cardiology, Buenos Aires 1115, Argentina; walter.masson@hospitalitaliano.org.ar (W.M.); augustolavalle@gmail.com (A.L.-C.) – name: 2 Endocrinology, Nutrition and Metabolism Investigation Center, Faculty of Health Science, National University of Formosa, Formosa 3600, Argentina |
| Author_xml | – sequence: 1 givenname: Walter orcidid: 0000-0002-5620-6468 surname: Masson fullname: Masson, Walter – sequence: 2 givenname: Augusto orcidid: 0000-0002-1257-9211 surname: Lavalle-Cobo fullname: Lavalle-Cobo, Augusto – sequence: 3 givenname: Juan Patricio surname: Nogueira fullname: Nogueira, Juan Patricio |
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| Title | Effect of SGLT2-Inhibitors on Epicardial Adipose Tissue: A Meta-Analysis |
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