Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation

• Published in: Blood Vol. 141; no. 14; pp. 1691 - 1707
• Main Authors: Zeng, Xiangjun, Li, Xiaoqing, Li, Xia, Wei, Cong, Shi, Ce, Hu, Kejia, Kong, Delin, Luo, Qian, Xu, Yulin, Shan, Wei, Zhang, Meng, Shi, Jimin, Feng, Jingjing, Han, Yingli, Huang, He, Qian, Pengxu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.04.2023
• Subjects: Animals; Cell Differentiation; Fecal Microbiota Transplantation; Hematopoiesis; Hematopoietic Stem Cells - metabolism; Inflammation - metabolism; Inflammation - therapy; Mice

•FMT from young mice restored lymphoid differentiative potential and improved the number and engraftment ability of aged HSCs.•Lachnospiraceae and tryptophan-associated metabolites could improve both the phenotype and the reconstitution capacity of HSCs in aged mice. [Display omitted] Hematopoietic...