Production of 1,2,4-butanetriol from xylose by Saccharomyces cerevisiae through Fe metabolic engineering

• Published in: Metabolic engineering Vol. 56; pp. 17 - 27
• Main Authors: Bamba, Takahiro, Yukawa, Takahiro, Guirimand, Gregory, Inokuma, Kentaro, Sasaki, Kengo, Hasunuma, Tomohisa, Kondo, Akihiko
• Format: Journal Article
• Language: English
• Published: Belgium Elsevier Inc 01.12.2019
• Subjects: 2-Ketoacid decarboxylase; biochemical pathways; Biomass utilization; Butanols - metabolism; drugs; enzyme activity; fermentation; Fe–S cluster; hydrolysates; iron; Iron - metabolism; Metabolic Engineering; Microorganisms, Genetically-Modified - genetics; Microorganisms, Genetically-Modified - metabolism; plasticizers; rice straw; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; screening; xylonate dehydratase; xylose; Xylose - metabolism; xylose isomerase; Yeast cell factory; Metabolic engineering; 2-Ketoacid decarboxylase; Fe–S cluster; xylonate dehydratase; Yeast cell factory; Biomass utilization

1,2,4-Butanetriol can be used to produce energetic plasticizer as well as several pharmaceutical compounds. Although Saccharomyces cerevisiae has some attractive characters such as high robustness for industrial production of useful chemicals by fermentation, 1,2,4-butanetriol production by S. cerev...