Cannabinoid pharmacology in cancer research: A new hope for cancer patients?

Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic...

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Published inEuropean journal of pharmacology Vol. 775; pp. 1 - 14
Main Authors Javid, Farideh A., Phillips, Roger M., Afshinjavid, S., Verde, Roberta, Ligresti, Alessia
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.03.2016
Subjects
Animals
Antineoplastic Agents - therapeutic use
Cancer
Cannabinoid receptors
Cannabinoids
Cannabinoids - therapeutic use
Humans
Neoplasms - drug therapy
FAAH
PR
Gi/o
TIMP-1
TRB3
AKt
Cdk
PRLr
HU-210
JWH-133
NF-κB
PI3K
TRPVA1
AM251
CB1IR
mTOR
TrK A
Src gene
Th1
AEA
PSA
Th2
Cannabinoid receptors
ABCC1
AC
PKA
JWH-015
NGF
ER
AR
MMP-2
PyMT
2-AG
ROS
AMPK
SC58236
MMP-9
ERK
PCNA
RXRα
CBD
LPI
CXCR4
SB203580
EGFR
AM630
HIF-α
Cannabinoids
GBM
GTPγS
WIN 55,212–2
PD98059
COX2
MAGL
TRPM8
SR141716
ATF-4
PGE2
MRP1
ICAM
VEGF
siRNA
TRPV1
PPARs
FAK
CXCL12
Chk 1
Δ9-THC
LAK
RAF-1
HER2
Cancer
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Abstract Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis, spinal cord injury, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity, and osteoporosis. Several studies have demonstrated that cannabinoids also have anti-cancer activity and as cannabinoids are usually well tolerated and do not produce the typical toxic effects of conventional chemotherapies, there is considerable merit in the development of cannabinoids as potential anticancer therapies. Whilst the presence of psychoactive effects of cannabinoids could prevent any progress in this field, recent studies have shown the value of the non-psychoactive components of cannabinoids in activating apoptotic pathways, inducing anti-proliferative and anti-angiogenic effects. The aforementioned effects are suggested to be through pathways such as ERK, Akt, mitogen-activated protein kinase (MAPK) pathways, phosphoinositide 3-kinase (PI3K) pathways and hypoxia inducible factor 1 (HIF1), all of which are important contributors to the hallmarks of cancer. Many important questions still remain unanswered or are poorly addressed thus necessitating further research at basic pre-clinical and clinical levels. In this review, we address these issues with a view to identifying the key challenges that future research needs to address.
AbstractList Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis, spinal cord injury, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity, and osteoporosis. Several studies have demonstrated that cannabinoids also have anti-cancer activity and as cannabinoids are usually well tolerated and do not produce the typical toxic effects of conventional chemotherapies, there is considerable merit in the development of cannabinoids as potential anticancer therapies. Whilst the presence of psychoactive effects of cannabinoids could prevent any progress in this field, recent studies have shown the value of the non-psychoactive components of cannabinoids in activating apoptotic pathways, inducing anti-proliferative and anti-angiogenic effects. The aforementioned effects are suggested to be through pathways such as ERK, Akt, mitogen-activated protein kinase (MAPK) pathways, phosphoinositide 3-kinase (PI3K) pathways and hypoxia inducible factor 1 (HIF1), all of which are important contributors to the hallmarks of cancer. Many important questions still remain unanswered or are poorly addressed thus necessitating further research at basic pre-clinical and clinical levels. In this review, we address these issues with a view to identifying the key challenges that future research needs to address.Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis, spinal cord injury, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity, and osteoporosis. Several studies have demonstrated that cannabinoids also have anti-cancer activity and as cannabinoids are usually well tolerated and do not produce the typical toxic effects of conventional chemotherapies, there is considerable merit in the development of cannabinoids as potential anticancer therapies. Whilst the presence of psychoactive effects of cannabinoids could prevent any progress in this field, recent studies have shown the value of the non-psychoactive components of cannabinoids in activating apoptotic pathways, inducing anti-proliferative and anti-angiogenic effects. The aforementioned effects are suggested to be through pathways such as ERK, Akt, mitogen-activated protein kinase (MAPK) pathways, phosphoinositide 3-kinase (PI3K) pathways and hypoxia inducible factor 1 (HIF1), all of which are important contributors to the hallmarks of cancer. Many important questions still remain unanswered or are poorly addressed thus necessitating further research at basic pre-clinical and clinical levels. In this review, we address these issues with a view to identifying the key challenges that future research needs to address.
Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of pathophysiological conditions, such as mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis, spinal cord injury, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity, and osteoporosis. Several studies have demonstrated that cannabinoids also have anti-cancer activity and as cannabinoids are usually well tolerated and do not produce the typical toxic effects of conventional chemotherapies, there is considerable merit in the development of cannabinoids as potential anticancer therapies. Whilst the presence of psychoactive effects of cannabinoids could prevent any progress in this field, recent studies have shown the value of the non-psychoactive components of cannabinoids in activating apoptotic pathways, inducing anti-proliferative and anti-angiogenic effects. The aforementioned effects are suggested to be through pathways such as ERK, Akt, mitogen-activated protein kinase (MAPK) pathways, phosphoinositide 3-kinase (PI3K) pathways and hypoxia inducible factor 1 (HIF1), all of which are important contributors to the hallmarks of cancer. Many important questions still remain unanswered or are poorly addressed thus necessitating further research at basic pre-clinical and clinical levels. In this review, we address these issues with a view to identifying the key challenges that future research needs to address.
Author Phillips, Roger M.
Ligresti, Alessia
Verde, Roberta
Afshinjavid, S.
Javid, Farideh A.
Author_xml – sequence: 1
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  givenname: Roger M.
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  givenname: Roberta
  surname: Verde
  fullname: Verde, Roberta
  organization: Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council of Italy, Pozzuoli, NA, Italy
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  surname: Ligresti
  fullname: Ligresti, Alessia
  organization: Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council of Italy, Pozzuoli, NA, Italy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26852955$$D View this record in MEDLINE/PubMed
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ISSN 0014-2999
1879-0712
IngestDate Fri Jul 11 02:46:51 EDT 2025
Thu Apr 03 07:02:35 EDT 2025
Thu Apr 24 23:02:55 EDT 2025
Tue Jul 01 02:49:58 EDT 2025
Fri Feb 23 02:27:57 EST 2024
IsPeerReviewed true
IsScholarly true
Keywords FAAH
PR
Gi/o
TIMP-1
TRB3
AKt
Cdk
PRLr
HU-210
JWH-133
NF-κB
PI3K
TRPVA1
AM251
CB1IR
mTOR
TrK A
Src gene
Th1
AEA
PSA
Th2
Cannabinoid receptors
ABCC1
AC
PKA
JWH-015
NGF
ER
AR
MMP-2
PyMT
2-AG
ROS
AMPK
SC58236
MMP-9
ERK
PCNA
RXRα
CBD
LPI
CXCR4
SB203580
EGFR
AM630
HIF-α
Cannabinoids
GBM
GTPγS
WIN 55,212–2
PD98059
COX2
MAGL
TRPM8
SR141716
ATF-4
PGE2
MRP1
ICAM
VEGF
siRNA
TRPV1
PPARs
FAK
CXCL12
Chk 1
Δ9-THC
LAK
RAF-1
HER2
Cancer
Language English
License Copyright © 2016 Elsevier B.V. All rights reserved.
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PublicationTitle European journal of pharmacology
PublicationTitleAlternate Eur J Pharmacol
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Snippet Cannabinoids have been used for many centuries to ease pain and in the past decade, the endocannabinoid system has been implicated in a number of...
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SubjectTerms Animals
Antineoplastic Agents - therapeutic use
Cancer
Cannabinoid receptors
Cannabinoids
Cannabinoids - therapeutic use
Humans
Neoplasms - drug therapy
Title Cannabinoid pharmacology in cancer research: A new hope for cancer patients?
URI https://dx.doi.org/10.1016/j.ejphar.2016.02.010
https://www.ncbi.nlm.nih.gov/pubmed/26852955
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