Antisense Therapy against CCR3 and the Common Beta Chain Attenuates Allergen-induced Eosinophilic Responses

• Published in: American journal of respiratory and critical care medicine Vol. 177; no. 9; pp. 952 - 958
• Main Authors: Gauvreau, Gail M, Boulet, Louis Philippe, Cockcroft, Donald W, Baatjes, Adrian, Cote, Johanne, Deschesnes, Francine, Davis, Beth, Strinich, Tara, Howie, Karen, Duong, MyLinh, Watson, Richard M, Renzi, Paolo M, O'Byrne, Paul M
• Format: Journal Article
• Language: English
• Published: New York, NY Am Thoracic Soc 01.05.2008; American Lung Association; American Thoracic Society
• Subjects: Administration, Inhalation; Adult; Allergens - adverse effects; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asthma - drug therapy; Asthma - genetics; Asthma - metabolism; Biological and medical sciences; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Flow Cytometry; Follow-Up Studies; Forced Expiratory Volume; Gene Expression; Humans; Intensive care medicine; Male; Medical sciences; Middle Aged; Nebulizers and Vaporizers; Oligonucleotides, Antisense - administration & dosage; Oligonucleotides, Antisense - therapeutic use; Pharmacology. Drug treatments; Phosphorothioate Oligonucleotides - administration & dosage; Phosphorothioate Oligonucleotides - therapeutic use; Pulmonary Eosinophilia - drug therapy; Pulmonary Eosinophilia - genetics; Pulmonary Eosinophilia - metabolism; Receptors, CCR3 - antagonists & inhibitors; Receptors, CCR3 - genetics; Receptors, CCR3 - metabolism; Receptors, Cytokine - genetics; Receptors, Cytokine - metabolism; Respiratory system; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Sputum - cytology; Sputum - metabolism; Treatment Outcome; airway inflammation; Immunopathology; Allergy; Intensive care; eosinophils; Inflammation; Chemokine receptor; Eosinophil; Inhalation; allergen inhalation; Treatment; antisense oligonucleotides; Resuscitation

The drug product TPI ASM8 contains two modified phosphorothioate antisense oligonucleotides designed to inhibit allergic inflammation by down-regulating human CCR3 and the common beta chain (beta(c)) of IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor receptors. This study examined t...