Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation

• Published in: International journal of oncology Vol. 43; no. 4; pp. 1117 - 1124
• Main Authors: MIZUSHINA, YOSHIYUKI, SHIOMI, KAZUAKI, KURIYAMA, ISOKO, TAKAHASHI, YOSHIHIRO, YOSHIDA, HIROMI
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.10.2013; Spandidos Publications UK Ltd
• Subjects: anticancer; Cancer; cancer cell proliferation; cell cycle arrest; Cell Cycle Checkpoints - drug effects; Cell Division - drug effects; Cell Proliferation - drug effects; Colonic Neoplasms - drug therapy; Colonic Neoplasms - enzymology; Colonic Neoplasms - pathology; DNA topoisomerase II; DNA Topoisomerases, Type II - biosynthesis; DNA Topoisomerases, Type II - chemistry; DNA Topoisomerases, Type II - genetics; enzyme inhibitor; genistein; Genistein - administration & dosage; Genistein - chemistry; Glycine max - chemistry; HCT116 Cells; Humans; Isoflavones - administration & dosage; Isoflavones - chemistry; Kinases; Protein Conformation - drug effects; soy isoflavones; Soy products; Soybeans; Structure-Activity Relationship; Japan

The inhibitory activity of 3 soy isoflavones (daidzein, genistein and glycitein) and their glycosides (daidzin, genistin and glycitin) on mammalian DNA polymerases (pols) and topoisomerases (topos) was investigated. Of the compounds tested, only genistein selectively inhibited human topo II activity...