Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation - MIZUSHINA, YOSHIYUKI; SHIOMI, KAZUAKI; KURIYAMA, ISOKO; TAKAHASHI, YOSHIHIRO; YOSHIDA, HIROMI (International journal of oncology, 2013)
Keywords: anticancer; Cancer; cancer cell proliferation; cell cycle arrest; Cell Cycle Checkpoints - drug effects; Cell Division - drug effects; Cell Proliferation - drug effects; Colonic Neoplasms - drug therapy; Colonic Neoplasms - enzymology; Colonic Neoplasms - pathology; DNA topoisomerase II; DNA Topoisomerases, Type II - biosynthesis; DNA Topoisomerases, Type II - chemistry; DNA Topoisomerases, Type II - genetics; enzyme inhibitor; genistein; Genistein - administration & dosage; Genistein - chemistry; Glycine max - chemistry; HCT116 Cells; Humans; Isoflavones - administration & dosage; Isoflavones - chemistry; Kinases; Protein Conformation - drug effects; soy isoflavones; Soy products; Soybeans; Structure-Activity Relationship; Japan