Applying chaperones to protein-misfolding disorders: Molecular chaperones against α-synuclein in Parkinson's disease

• Published in: International journal of biological macromolecules Vol. 60; pp. 196 - 205
• Main Authors: Chaari, Ali, Hoarau-Véchot, Jessica, Ladjimi, Moncef
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2013
• Subjects: Aggregation; alpha-Synuclein - chemistry; alpha-Synuclein - metabolism; amyloid; animal disease models; Animals; Biomarkers; dopamine; heat shock proteins; Heat-Shock Proteins - chemistry; Heat-Shock Proteins - metabolism; Humans; idiopathic diseases; Lewy bodies; Lewy Bodies - metabolism; Molecular chaperones; Molecular Chaperones - chemistry; Molecular Chaperones - metabolism; Parkinson disease; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; protein aggregates; Protein Folding; Proteostasis Deficiencies - metabolism; Refolding; α-synuclein; Aggregation; Parkinson's disease; PD; Hsp; Molecular chaperones; α-syn; LB; Refolding; sHsp; α-synuclein; heat shock protein; small heat shock protein; Lewy body

•Refolding protein is the key for neurodegenerative disorder.•Protein chaperones can be a target for therapeutic intervention in Parkinson's disease.•The various molecular chaperones have a complementary effect in PD. Parkinson's disease (PD) is a neurodegenerative disorder characterized b...