Dissecting major depression: The role of blood biomarkers and adverse childhood experiences in distinguishing clinical subgroups

• Published in: Journal of affective disorders Vol. 276; pp. 351 - 360
• Main Authors: Lo Iacono, Luisa, Bussone, Silvia, Andolina, Diego, Tambelli, Renata, Troisi, Alfonso, Carola, Valeria
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2020
• Subjects: Adverse Childhood Experiences; Biomarkers; Child; Childhood Trauma Questionnaire; Cross-Sectional Studies; Depression; Depressive Disorder, Major - diagnosis; Global DNA methylation; Humans; Intracellular Signaling Peptides and Proteins; Major depressive disorder; MicroRNA-34a; Parental bonding instrument; Psychiatric/Mental Health; SIRT1; TOLLIP; VEGF-a; Parental bonding instrument; MicroRNA-34a; Global DNA methylation; TOLLIP; VEGF-a; Adverse childhood experiences; Childhood Trauma Questionnaire; SIRT1; Major depressive disorder

•Biomarkers and early-life parental care were assessed to identify subgroups of Major Depression Disorder (MDD) patients.•TOLLIP, VEGF-a, and global DNA methylation were differentially expressed between MDD patients and healthy subjects.•SIRT1 differences were modulated by quality of early-life pare...