The safety of ultrasonically guided testis aspiration biopsies and efficacy of use to predict varicocelectomy outcome

• Published in: Human reproduction (Oxford) Vol. 20; no. 8; pp. 2279 - 2288
• Main Authors: Marmar, Joel L., Benoff, Susan
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.08.2005; Oxford Publishing Limited (England)
• Subjects: Biological and medical sciences; Biomarkers; biopsy; Biopsy, Needle - adverse effects; Biopsy, Needle - methods; Cadmium - metabolism; Calcium Channels, L-Type - genetics; Gynecology. Andrology. Obstetrics; Humans; Infertility, Male - diagnostic imaging; Infertility, Male - pathology; Infertility, Male - surgery; Male; Medical sciences; percutaneous aspiration; Postoperative Complications; Predictive Value of Tests; RNA, Messenger - analysis; Sperm Count; testis; Testis - diagnostic imaging; Testis - metabolism; Testis - pathology; Treatment Outcome; Ultrasonography; ultrasound; varicocele; Varicocele - diagnostic imaging; Varicocele - pathology; Varicocele - surgery; biopsy; percutaneous aspiration; testis; ultrasound; varicocele; Sonography; Varicocele; Prognosis; Aspiration; biopsy/percutaneous aspiration/testis/ultrasound/varicocele; Male genital system; Percutaneous route; Vertebrata; Mammalia; Biopsy; Surgery; Safety; Male genital diseases; Ultrasound; Testicular diseases

BACKGROUND: We hypothesized that infertile men with varicoceles have molecular/genetic defects that interact with varicoceles to induce infertility. Studies directly on testis tissue appeared to be a way to link histology, markers for molecular/genetic defects and spermatogenesis, but testis biopsie...