OCT parameters of the optic nerve head and the retina as surrogate markers of brain volume in a normal population, a pilot study

• Published in: Journal of the neurological sciences Vol. 420; p. 117213
• Main Authors: Mejia-Vergara, Alvaro J., Karanjia, Rustum, Sadun, Alfredo A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2021
• Subjects: Biomarkers; Brain volume; Cross-Sectional Studies; Entorhinal cortex; Nerve Fibers; Neurology; Normal subjects; Optic coherence tomography; Optic Disk - diagnostic imaging; Optic nerve; Pilot Projects; Retina; Retina - diagnostic imaging; Retina ganglion cell layer; Retina nerve fiber layer; Retrospective Studies; Tomography, Optical Coherence; Visual cortex; OCT; Visual cortex; Optic nerve; AD; RNFL; MRI; Retina nerve fiber layer; Retina; SD; Normal subjects; Entorhinal cortex; Brain volume; Optic coherence tomography; Retina ganglion cell layer; GCL-IPL; PVC; ICV; Total intracranial Volume; magnetic resonance imaging; primary visual cortex; Peripapillary retinal nerve fiber layer; complex ganglion cell-inner plexiform layer; Alzheimer's disease; standard deviation

The relationship between optical coherence tomography (OCT) measurements of the retinal structures has been described for various neurological diseases including Multiple Sclerosis (MS), Alzheimer's disease (AD) and Parkinson's disease (PD). Brain volume changes, both globally and by area,...