Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice
Alzheimer's disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the AD intervention from treatment to prevention in the at-risk population. Previous studie...
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Published in | Translational psychiatry Vol. 10; no. 1; p. 230 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , |
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Language | English |
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Nature Publishing Group
13.07.2020
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Abstract | Alzheimer's disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the AD intervention from treatment to prevention in the at-risk population. Previous studies suggest that there is a geographic overlap between AD incidence and spicy food consumption. We previously reported that capsaicin-rich diet consumption was associated with better cognition and lower serum Amyloid-beta (Aβ) levels in people aged 40 years and over. In the present study, we found that intake of capsaicin, the pungent ingredient in chili peppers, reduced brain Aβ burden and rescued cognitive decline in APP/PS1 mice. Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards α-cleavage and precluded Aβ generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10). We also found that capsaicin alleviated other AD-type pathologies, such as tau hyperphosphorylation, neuroinflammation and neurodegeneration. The present study suggests that capsaicin is a potential therapeutic candidate for AD and warrants clinical trials on chili peppers or capsaicin as dietary supplementation for the prevention and treatment of AD. |
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AbstractList | Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the AD intervention from treatment to prevention in the at-risk population. Previous studies suggest that there is a geographic overlap between AD incidence and spicy food consumption. We previously reported that capsaicin-rich diet consumption was associated with better cognition and lower serum Amyloid-beta (Aβ) levels in people aged 40 years and over. In the present study, we found that intake of capsaicin, the pungent ingredient in chili peppers, reduced brain Aβ burden and rescued cognitive decline in APP/PS1 mice. Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards α-cleavage and precluded Aβ generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10). We also found that capsaicin alleviated other AD-type pathologies, such as tau hyperphosphorylation, neuroinflammation and neurodegeneration. The present study suggests that capsaicin is a potential therapeutic candidate for AD and warrants clinical trials on chili peppers or capsaicin as dietary supplementation for the prevention and treatment of AD. Abstract Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the establishment of modifiable risk factors have shifted the AD intervention from treatment to prevention in the at-risk population. Previous studies suggest that there is a geographic overlap between AD incidence and spicy food consumption. We previously reported that capsaicin-rich diet consumption was associated with better cognition and lower serum Amyloid-beta (Aβ) levels in people aged 40 years and over. In the present study, we found that intake of capsaicin, the pungent ingredient in chili peppers, reduced brain Aβ burden and rescued cognitive decline in APP/PS1 mice. Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards α-cleavage and precluded Aβ generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10). We also found that capsaicin alleviated other AD-type pathologies, such as tau hyperphosphorylation, neuroinflammation and neurodegeneration. The present study suggests that capsaicin is a potential therapeutic candidate for AD and warrants clinical trials on chili peppers or capsaicin as dietary supplementation for the prevention and treatment of AD. |
ArticleNumber | 230 |
Author | Shen, Lin-Lin Jin, Wang-Sheng Wang, Zhen Wang, Yan-Jiang Tian, Ding-Yuan Zhu, Zhi-Ming Bu, Xian-Le Wang, Jun Xu, Wei Xiang, Yang Chen, Li-Yong Chen, Xiao-Wei Zeng, Gui-Hua Yu, Jin-Tai Li, Wei-Wei Sun, Bin-Lu Liu, Yu-Hui Hu, Zhian Zhu, Chi Song, Weihong Zhou, Hua-Dong |
Author_xml | – sequence: 1 givenname: Jun surname: Wang fullname: Wang, Jun email: qywangjun@163.com organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China. qywangjun@163.com – sequence: 2 givenname: Bin-Lu surname: Sun fullname: Sun, Bin-Lu organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 3 givenname: Yang surname: Xiang fullname: Xiang, Yang organization: Department of Neurology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, 610072, Chengdu, China – sequence: 4 givenname: Ding-Yuan surname: Tian fullname: Tian, Ding-Yuan organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 5 givenname: Chi surname: Zhu fullname: Zhu, Chi organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 6 givenname: Wei-Wei surname: Li fullname: Li, Wei-Wei organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 7 givenname: Yu-Hui surname: Liu fullname: Liu, Yu-Hui organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 8 givenname: Xian-Le orcidid: 0000-0002-2331-3339 surname: Bu fullname: Bu, Xian-Le organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 9 givenname: Lin-Lin surname: Shen fullname: Shen, Lin-Lin organization: Shigatse Branch, Xinqiao Hospital, Third Military Medical University, 857000, Shigatse, China – sequence: 10 givenname: Wang-Sheng surname: Jin fullname: Jin, Wang-Sheng organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 11 givenname: Zhen surname: Wang fullname: Wang, Zhen organization: Department of anaesthesiology, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 12 givenname: Gui-Hua surname: Zeng fullname: Zeng, Gui-Hua organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 13 givenname: Wei surname: Xu fullname: Xu, Wei organization: Department of Neurology, Qingdao Municipal Hospital, Qingdao University, 266071, Qingdao, China – sequence: 14 givenname: Li-Yong surname: Chen fullname: Chen, Li-Yong organization: Department of anaesthesiology, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 15 givenname: Xiao-Wei orcidid: 0000-0003-0906-6666 surname: Chen fullname: Chen, Xiao-Wei organization: Brain Research Center, Third Military Medical University, 400038, Chongqing, China – sequence: 16 givenname: Zhian surname: Hu fullname: Hu, Zhian organization: Department of Physiology and Institute of Brain and Intelligence, Third Military Medical University, 400038, Chongqing, China – sequence: 17 givenname: Zhi-Ming surname: Zhu fullname: Zhu, Zhi-Ming organization: Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 18 givenname: Weihong orcidid: 0000-0001-9928-889X surname: Song fullname: Song, Weihong organization: Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada – sequence: 19 givenname: Hua-Dong surname: Zhou fullname: Zhou, Hua-Dong organization: Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 400042, Chongqing, China – sequence: 20 givenname: Jin-Tai surname: Yu fullname: Yu, Jin-Tai organization: Department of Neurology, Huashan Hospital, Fudan University, 200040, Shanghai, China – sequence: 21 givenname: Yan-Jiang orcidid: 0000-0002-6227-6112 surname: Wang fullname: Wang, Yan-Jiang email: yanjiang_wang@tmmu.edu.cn, yanjiang_wang@tmmu.edu.cn, yanjiang_wang@tmmu.edu.cn organization: Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, 200031, Shanghai, China. yanjiang_wang@tmmu.edu.cn |
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Snippet | Alzheimer's disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the... Abstract Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the... Alzheimer’s disease (AD) is the most common cause of age-related dementia and is currently incurable. The failures of current clinical trials and the... |
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SubjectTerms | Alzheimer Disease - drug therapy Alzheimer Disease - prevention & control Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Animals Brain - metabolism Capsaicin - pharmacology Clinical trials Cognition Cognitive Dysfunction - drug therapy Cognitive Dysfunction - prevention & control Disease Models, Animal Mice Mice, Transgenic Presenilin-1 - metabolism |
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Title | Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice |
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