MFAP4-Mediated Effects in Elastic Fiber Homeostasis, Integrin Signaling and Cancer, and Its Role in Teleost Fish

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 13; p. 2115
• Main Authors: Mohammadi, Ali, Sorensen, Grith L., Pilecki, Bartosz
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 05.07.2022; MDPI
• Subjects: Angiogenesis; Binding sites; Bioavailability; Blood vessels; Cancer; Cell adhesion & migration; Chemical bonds; elastic fiber; Elastin; Extracellular matrix; Fibrinogen; Fibroblasts; Fibrosis; Genes; Genomes; Glycoproteins; Heparan sulfate; Homeostasis; integrin signaling; Kinases; Liver cancer; Liver diseases; Localization; Macrophages; MFAP4; Physiology; Proteins; Review; Signal transduction; Smooth muscle

Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix (ECM) protein belonging to the fibrinogen-related domain superfamily. MFAP4 is highly expressed in elastin-rich tissues such as lung, blood vessels and skin. MFAP4 is involved in organization of the ECM, regulating proper elastic...