MFAP4-Mediated Effects in Elastic Fiber Homeostasis, Integrin Signaling and Cancer, and Its Role in Teleost Fish

Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix (ECM) protein belonging to the fibrinogen-related domain superfamily. MFAP4 is highly expressed in elastin-rich tissues such as lung, blood vessels and skin. MFAP4 is involved in organization of the ECM, regulating proper elastic...

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Published inCells (Basel, Switzerland) Vol. 11; no. 13; p. 2115
Main Authors Mohammadi, Ali, Sorensen, Grith L., Pilecki, Bartosz
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 05.07.2022
MDPI
Subjects
Angiogenesis
Binding sites
Bioavailability
Blood vessels
Cancer
Cell adhesion & migration
Chemical bonds
elastic fiber
Elastin
Extracellular matrix
Fibrinogen
Fibroblasts
Fibrosis
Genes
Genomes
Glycoproteins
Heparan sulfate
Homeostasis
integrin signaling
Kinases
Liver cancer
Liver diseases
Localization
Macrophages
MFAP4
Physiology
Proteins
Review
Signal transduction
Smooth muscle
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Abstract Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix (ECM) protein belonging to the fibrinogen-related domain superfamily. MFAP4 is highly expressed in elastin-rich tissues such as lung, blood vessels and skin. MFAP4 is involved in organization of the ECM, regulating proper elastic fiber assembly. On the other hand, during pathology MFAP4 actively contributes to disease development and progression due to its interactions with RGD-dependent integrin receptors. Both tissue expression and circulating MFAP4 levels are associated with various disorders, including liver fibrosis and cancer. In other experimental models, such as teleost fish, MFAP4 appears to participate in host defense as a macrophage-specific innate immune molecule. The aim of this review is to summarize the accumulating evidence that indicates the importance of MFAP4 in homeostasis as well as pathological conditions, discuss its known biological functions with special focus on elastic fiber assembly, integrin signaling and cancer, as well as describe the reported functions of non-mammalian MFAP4 in fish. Overall, our work provides a comprehensive overview on the role of MFAP4 in health and disease.
AbstractList Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix (ECM) protein belonging to the fibrinogen-related domain superfamily. MFAP4 is highly expressed in elastin-rich tissues such as lung, blood vessels and skin. MFAP4 is involved in organization of the ECM, regulating proper elastic fiber assembly. On the other hand, during pathology MFAP4 actively contributes to disease development and progression due to its interactions with RGD-dependent integrin receptors. Both tissue expression and circulating MFAP4 levels are associated with various disorders, including liver fibrosis and cancer. In other experimental models, such as teleost fish, MFAP4 appears to participate in host defense as a macrophage-specific innate immune molecule. The aim of this review is to summarize the accumulating evidence that indicates the importance of MFAP4 in homeostasis as well as pathological conditions, discuss its known biological functions with special focus on elastic fiber assembly, integrin signaling and cancer, as well as describe the reported functions of non-mammalian MFAP4 in fish. Overall, our work provides a comprehensive overview on the role of MFAP4 in health and disease.
Author Pilecki, Bartosz
Mohammadi, Ali
Sorensen, Grith L
AuthorAffiliation Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark; amohammadi@health.sdu.dk (A.M.); glsorensen@health.sdu.dk (G.L.S.)
AuthorAffiliation_xml – name: Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark; amohammadi@health.sdu.dk (A.M.); glsorensen@health.sdu.dk (G.L.S.)
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  surname: Pilecki
  fullname: Pilecki, Bartosz
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Snippet Microfibrillar-associated protein 4 (MFAP4) is an extracellular matrix (ECM) protein belonging to the fibrinogen-related domain superfamily. MFAP4 is highly...
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SubjectTerms Angiogenesis
Binding sites
Bioavailability
Blood vessels
Cancer
Cell adhesion & migration
Chemical bonds
elastic fiber
Elastin
Extracellular matrix
Fibrinogen
Fibroblasts
Fibrosis
Genes
Genomes
Glycoproteins
Heparan sulfate
Homeostasis
integrin signaling
Kinases
Liver cancer
Liver diseases
Localization
Macrophages
MFAP4
Physiology
Proteins
Review
Signal transduction
Smooth muscle
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Title MFAP4-Mediated Effects in Elastic Fiber Homeostasis, Integrin Signaling and Cancer, and Its Role in Teleost Fish
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Volume 11
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