Multiple Myeloma Treatment Transformed: A Population-Based Study of Changes in Initial Management Approaches in the United States

• Published in: Journal of clinical oncology Vol. 31; no. 16; pp. 1984 - 1989
• Main Authors: WARREN, Joan L, HARLAN, Linda C, STEVENS, Jennifer, LITTLE, Richard F, ABEL, Gregory A
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Society of Clinical Oncology 01.06.2013
• Subjects: Adult; African Americans - statistics & numerical data; Aged; Antineoplastic Agents - economics; Antineoplastic Agents - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Asian Americans - statistics & numerical data; Biological and medical sciences; Confounding Factors (Epidemiology); Doxorubicin - administration & dosage; European Continental Ancestry Group - statistics & numerical data; Female; Hematopoietic Stem Cell Transplantation - economics; Hispanic Americans - statistics & numerical data; Humans; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulinopathies; Immunopathology; Insurance, Health - statistics & numerical data; Logistic Models; Male; Medicaid; Medical sciences; Medicare; Melphalan - administration & dosage; Middle Aged; Molecular Targeted Therapy - economics; Molecular Targeted Therapy - trends; Molecular Targeted Therapy - utilization; Multiple Myeloma - drug therapy; Multiple Myeloma - economics; Multiple Myeloma - surgery; Multiple Myeloma - therapy; ORIGINAL REPORTS; Practice Patterns, Physicians' - economics; Practice Patterns, Physicians' - trends; Retrospective Studies; SEER Program; Transplantation, Autologous; Treatment Outcome; Tumors; United States; Vincristine - administration & dosage; United States; North America; America; Immunopathology; Cancerology; Clinical management; Treatment; Immunoglobulinopathy; Lymphoproliferative syndrome; Malignant hemopathy; Change; Myeloma; Statistical study; Cancer

Despite improved outcomes for multiple myeloma, little is known about changes in initial treatment at the population level for US patients. We report trends in treatment practices. Patients (n = 1,976) with newly diagnosed myeloma in 1999, 2003, and 2007 were examined by using the National Cancer In...